Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 10/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 10/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 10/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 10/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 10/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 10/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.39 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.38 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.37 |
| ▸ | ABAT | P80404 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8032866 | 0.85 | ALDH1A3 (0.50) | ALDH1A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL758449 | 0.82 | ALDH1A1 (0.48) | ALDH1A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL30668617 | 0.82 | ALDH1A1 (0.48) | ALDH1A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL12825372 | 0.82 | PSEN1 (0.39) | ALDH1A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL29940580 | 0.80 | PSEN1 (0.57) | ALDH1A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL758550 | 0.80 | PSEN1 (0.57) | ALDH1A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7841275 | 0.80 | PDK1 (0.40) | KDM4ERAB9AALDH1A1PSEN1PSEN2 | |
| SCHEMBL1238787 | 0.78 | ALDH1A1 (0.50) | KDM4EALDH1A1PSEN1PSEN2APH1B | |
| SCHEMBL8039532 | 0.78 | TTR (0.60) | RAB9APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7935796 | 0.77 | TSHR (0.43) | KDM4EALDH1A1PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009020580-A1 | GAMMA SECRETASE MODULATORS | SCHERING CORPORATION (US) | 2009-02-12 | — | — | WO | disclosed |