Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.77 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.60 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.56 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.56 |
| ▸ | GCK | P35557 | 2/20 | 0.55 |
| ▸ | MAOB | P27338 | 3/20 | 0.54 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.53 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1776182 | 0.93 | MEN1 (0.75) | MEN1KMT2ANR4A2NR4A1NR4A3 | |
| SCHEMBL3488958 | 0.93 | MEN1 (0.75) | MEN1KMT2ANR4A2NR4A1NR4A3 | |
| SCHEMBL21924243 | 0.88 | MEN1 (0.82) | MEN1KMT2ANR4A2NR4A1NR4A3 | |
| SCHEMBL21924252 | 0.88 | MEN1 (0.82) | MEN1KMT2ANR4A2NR4A1NR4A3 | |
| SCHEMBL1426961 | 0.88 | MEN1 (1.00) | MEN1KMT2ANR4A2NR4A1NR4A3 | |
| SCHEMBL2651146 | 0.87 | KMT2A (0.79) | MEN1KMT2ANR4A2NR4A1NR4A3 | |
| SCHEMBL29788233 | 0.87 | MEN1 (0.84) | MEN1KMT2ANR4A2NR4A1NR4A3 | |
| SCHEMBL340452 | 0.87 | MEN1 (0.84) | MEN1KMT2ANR4A2NR4A1NR4A3 | |
| Hydrochloric Acid SCHEMBL6841086 | 0.86 | MEN1 (0.96) | MEN1KMT2ANR4A2NR4A1NR4A3 | |
| SCHEMBL23352170 | 0.86 | PLA2G2A (0.64) | MEN1KMT2ARAB9ATP53PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000038-B1 | NOVEL PYRIMIDIN DERIVATIVES | ASTRAZENECA AB (SE) | 2002-11-06 | — | — | EP | disclosed |
| US-6200981-B1 | FOR TREATING INFLAMMATORY DISEASES SUCH AS ASTHMA, INFLAMMATORY BOWEL DISEASE, PSORIASIS, RHEUMATOID ARTHRITIS, MYOCARDIAL ISCHAEMIA, CYSTIC FIBROSIS, ARTHEREOSCLEROSIS, RESTENOSIS, PERIDONTAL DISEASE, SEPTIC SHOCK, OSTEOARTHRITIS | ASTRAZENECA UK LIMITED (GB) | 2001-03-13 | — | — | US | disclosed |
| EP-1000038-A1 | NOVEL PYRIMIDIN DERIVATIVES | AstraZeneca UK Limited (GB) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999005123-A1 | NOVEL PYRIMIDIN DERIVATIVES | ASTRAZENECA UK LIMITED (GB) | 1999-02-04 | — | — | WO | disclosed |