SCHEMBL7597111

SCHEMBL7597111

COC(=O)C1=Cc2sccc2CC1C(=O)OC

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 7/20 0.45
NPC1 O15118 1/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
CNR2 P34972 1/20 0.35
ALDH1A1 P00352 7/20 0.34
MAPT P10636 6/20 0.34
RXFP1 Q9HBX9 2/20 0.34
MEN1 O00255 4/20 0.33
KDM4E B2RXH2 3/20 0.33
HSD17B10 Q99714 3/20 0.33
NPSR1 Q6W5P4 3/20 0.33
TSHR P16473 3/20 0.33
L3MBTL1 Q9Y468 2/20 0.33
RECQL P46063 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
HPGD P15428 2/20 0.33
GLA P06280 1/20 0.33
GAA P10253 1/20 0.33
CASP1 P29466 1/20 0.33
CASP7 P55210 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7597119 0.89 KMT2A (0.45) KMT2ASMN1; SMN2CNR2ALDH1A1MAPT
SCHEMBL20383513 0.72 ALDH1A1 (0.47) KMT2AALDH1A1KDM4EHSD17B10TSHR
SCHEMBL2834961 0.72 ALDH1A1 (0.47) KMT2AALDH1A1KDM4EHSD17B10TSHR
SCHEMBL7595087 0.70 CNR2 (0.38) KMT2ANPC1SMN1; SMN2CNR2ALDH1A1
Hydrochloric Acid SCHEMBL10489396 0.67 KMT2A (0.34) KMT2ANPC1SMN1; SMN2CNR2ALDH1A1
SCHEMBL2340043 0.66 KCNH2 (0.49) SMN1; SMN2ALDH1A1MAPTKDM4EHSD17B10
SCHEMBL7120249 0.64 KMT2A (0.52) KMT2ASMN1; SMN2ALDH1A1MAPTKDM4E
SCHEMBL23480476 0.64 KMT2A (0.49) KMT2AALDH1A1MAPTKDM4EHSD17B10
SCHEMBL7519445 0.64 KMT2A (0.60) KMT2AALDH1A1MAPT
SCHEMBL7613074 0.64 KMT2A (0.56) KMT2AALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0690054-B1 1-Amino-2-cyclohexene derivatives and production process therefor KURARAY CO (JP) 2002-11-20 EP disclosed
US-5587486-A CONDENSATION; CARBONYLATION; HYDROLYSIS; INTERMEDIATES IN THE PRODUCTION OF MEDICINAL AND AGRICULTURAL AGENTS KURARAY CO., LTD. (JP) 1996-12-24 US disclosed
EP-0690054-A1 1-Amino-2-cyclohexene derivatives and production process therefor KURARAY CO., LTD. (JP) 1996-01-03 EP disclosed