Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | XBP1 | P17861 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | GCGR | P47871 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | P4HB | P07237 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7597118 | 1.00 | ALDH1A1 (0.52) | ALDH1A1HTTXBP1RAB9AKMT2A | |
| SCHEMBL7510531 | 0.81 | ALDH1A1 (0.49) | ALDH1A1HTTXBP1RAB9AKMT2A | |
| SCHEMBL7508038 | 0.81 | USP30 (0.47) | ALDH1A1HTTXBP1RAB9AKMT2A | |
| SCHEMBL7570474 | 0.81 | EPHX2 (0.40) | ALDH1A1KMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL19658774 | 0.75 | ALDH1A1 (0.78) | ALDH1A1HTTXBP1RAB9AKMT2A | |
| SCHEMBL7597072 | 0.73 | ALDH1A1 (0.49) | ALDH1A1HTTXBP1RAB9AKMT2A | |
| SCHEMBL7597067 | 0.73 | ALDH1A1 (0.49) | ALDH1A1HTTXBP1RAB9AKMT2A | |
| SCHEMBL4565540 | 0.72 | HTT (0.61) | ALDH1A1HTTXBP1RAB9AKMT2A | |
| SCHEMBL1888953 | 0.71 | ALDH1A1 (0.48) | ALDH1A1HTTXBP1RAB9AKMT2A | |
| SCHEMBL14299385 | 0.70 | ALDH1A1 (0.70) | ALDH1A1HTTXBP1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1198463-A2 | COMPOUNDS FOR USE IN TREATMENT OF NEUROLOGICAL DISORDERS | AstraZeneca UK Limited (GB) | 2002-04-24 | — | — | EP | disclosed |
| WO-2000078751-A2 | COMPOUNDS FOR USE IN TREATMENT OF NEUROLOGICAL DISORDERS | ASTRAZENECA UK LIMITED (GB) | 2000-12-28 | — | — | WO | disclosed |