Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 7/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7597122 | 0.81 | ALDH1A1 (0.52) | EPHX2KMT2AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL7597118 | 0.81 | ALDH1A1 (0.52) | EPHX2KMT2AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL7517086 | 0.74 | HTR2C (0.38) | KMT2ARYR2MEN1 | |
| SCHEMBL7517081 | 0.74 | HTR2C (0.38) | KMT2ARYR2MEN1 | |
| SCHEMBL12126922 | 0.70 | MAOA (0.40) | KMT2AALDH1A1MEN1 | |
| SCHEMBL3950125 | 0.67 | NPC1 (0.42) | KMT2AMEN1 | |
| SCHEMBL12516865 | 0.66 | L3MBTL3 (0.53) | EPHX2ALDH1A1 | |
| SCHEMBL22063182 | 0.66 | EPHX2 (0.55) | EPHX2BLMCHRM4CHRM1BRD4 | |
| SCHEMBL7550905 | 0.65 | SIGMAR1 (0.41) | — | |
| SCHEMBL18909095 | 0.65 | EPHX2 (0.42) | EPHX2KMT2AALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1198463-A2 | COMPOUNDS FOR USE IN TREATMENT OF NEUROLOGICAL DISORDERS | AstraZeneca UK Limited (GB) | 2002-04-24 | — | — | EP | disclosed |
| WO-2000078751-A2 | COMPOUNDS FOR USE IN TREATMENT OF NEUROLOGICAL DISORDERS | ASTRAZENECA UK LIMITED (GB) | 2000-12-28 | — | — | WO | disclosed |