Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 8/20 | 0.46 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.42 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.41 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7594842 | 0.83 | ALDH1A1 (0.54) | ALDH1A1ESR1CYP3A4ESR2ALOX5AP | |
| SCHEMBL7596217 | 0.82 | ALDH1A1 (0.52) | ALDH1A1ESR1CYP3A4ESR2ALOX5AP | |
| SCHEMBL7599843 | 0.81 | ALDH1A1 (0.48) | ALDH1A1ESR1CYP3A4ESR2FFAR1 | |
| SCHEMBL30538032 | 0.80 | CYSLTR1 (0.67) | FFAR1ALOX5APCYSLTR2CYSLTR1ALOX5 | |
| SCHEMBL6440668 | 0.80 | CYSLTR1 (0.67) | FFAR1ALOX5APCYSLTR2CYSLTR1ALOX5 | |
| SCHEMBL28205576 | 0.79 | ALDH1A1 (0.60) | ALDH1A1ESR1CYP3A4ESR2FFAR1 | |
| SCHEMBL3048640 | 0.79 | CYSLTR1 (0.66) | FFAR1ALOX5APCYSLTR2CYSLTR1ALOX5 | |
| SCHEMBL7595258 | 0.79 | CYSLTR1 (0.66) | FFAR1ALOX5APCYSLTR2CYSLTR1ALOX5 | |
| SCHEMBL3048632 | 0.79 | CYSLTR1 (0.66) | FFAR1ALOX5APCYSLTR2CYSLTR1ALOX5 | |
| SCHEMBL7599591 | 0.77 | ALDH1A1 (0.57) | ALDH1A1ESR1CYP3A4ESR2FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0862557-B1 | SYMMETRICAL bis-HETEROARYLMETHOXYPHENYLALKYL CARBOXYLATES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LAB (US) | 2002-11-27 | — | — | EP | disclosed |
| US-5843968-A | Symmetrical bis-heteroarylmethoxy-phenylalkyl carboxylates as inhibitors of leukotriene biosynthesis | ABBOTT LABORATORIES (US) | 1998-12-01 | — | — | US | disclosed |
| US-5795900-A | Symmetrical bis-heteroaryl-methoxy-phenylalkyl carboxylates as inhibitors of leukotriene biosynthesis | ABBOTT LABORATORIES (US) | 1998-08-18 | — | — | US | disclosed |