Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 13/20 | 0.55 |
| ▸ | PTPN2 | P17706 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PTPN5 | P54829 | 3/20 | 0.34 |
| ▸ | PTPRC | P08575 | 2/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | RXRG | P48443 | 1/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
| ▸ | THRA | P10827 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7190920 | 0.89 | PTPN1 (0.57) | PTPN1PTPN2 | |
| SCHEMBL7189804 | 0.88 | PTPN5 (0.43) | PTPN1PTPN2PTPN5PTPRC | |
| SCHEMBL7189795 | 0.88 | PTPN1 (0.54) | PTPN1PTPN2KDM4EPTPN5RXRA | |
| SCHEMBL7597536 | 0.87 | PTPN1 (0.56) | PTPN1PTPN2PTPN5PTPRCRXRA | |
| SCHEMBL7665155 | 0.87 | PTPN5 (0.44) | PTPN1PTPN2PTPN5 | |
| SCHEMBL7597546 | 0.83 | PTPN1 (0.36) | PTPN1KDM4EXDHTHRATHRB | |
| SCHEMBL7189808 | 0.80 | KDM4E (0.37) | PTPN1KDM4ERXRARXRBRXRG | |
| SCHEMBL7181977 | 0.80 | PTPN1 (0.49) | PTPN1PTPN2KDM4EPTPRC | |
| SCHEMBL7665158 | 0.78 | KDM4E (0.36) | PTPN1KDM4E | |
| SCHEMBL7188046 | 0.77 | PTPN1 (0.55) | PTPN1PTPN2PTPRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6498151-B2 | PROTEIN TYROSINE PHOSPHATASES INHIBITORS, ESPECIALLY AS ANTIDIABETIC AGENTS | MERCK FROSST CANADA & CO. (CA) | 2002-12-24 | — | — | US | disclosed |
| US-20020091104-A1 | Aryldifluoromethylphosphonic acids with sulfur-containing substituents as PTP-1B inhibitors | MERCK FROSST CANADA LTD. (CA) | 2002-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020091104-A1 | Aryldifluoromethylphosphonic acids with sulfur-containing substituents as PTP-1B inhibitors | PTPRF, PTPRS, PTPRO | PTPN1 13/4885PTPN2 24/4885KDM4E 2275/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.