Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.30 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.30 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7189808 | 0.94 | KDM4E (0.37) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL7597546 | 0.87 | PTPN1 (0.36) | KDM4EPTPN1 | |
| SCHEMBL7665155 | 0.84 | PTPN5 (0.44) | PTPN1 | |
| SCHEMBL7189804 | 0.80 | PTPN5 (0.43) | PTPN1 | |
| SCHEMBL7597545 | 0.78 | PTPN1 (0.55) | KDM4EPTPN1 | |
| SCHEMBL7189802 | 0.74 | KDM4E (0.39) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL7591806 | 0.72 | GGPS1 (0.38) | KDM4ESMN1; SMN2PTPN1POLB | |
| SCHEMBL7558349 | 0.71 | PTPN1 (0.53) | PTPN1 | |
| SCHEMBL7190925 | 0.67 | PTPN1 (0.35) | MEN1KMT2ASMN1; SMN2PTPN1NPC1 | |
| SCHEMBL7186784 | 0.67 | ALDH1A1 (0.44) | KDM4EALDH1A1SMN1; SMN2PTPN1ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6498151-B2 | PROTEIN TYROSINE PHOSPHATASES INHIBITORS, ESPECIALLY AS ANTIDIABETIC AGENTS | MERCK FROSST CANADA & CO. (CA) | 2002-12-24 | — | — | US | claimed |