Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN5 | P54829 | 14/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.41 |
| ▸ | PGK1 | P00558 | 3/20 | 0.39 |
| ▸ | PGK2 | P07205 | 3/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.36 |
| ▸ | PTPRB | P23467 | 1/20 | 0.36 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7189804 | 0.93 | PTPN5 (0.43) | PTPN5PTPN1PTPN2PTPRBPTPN6 | |
| SCHEMBL7597545 | 0.87 | PTPN1 (0.55) | PTPN5PTPN1PTPN2 | |
| SCHEMBL7665158 | 0.84 | KDM4E (0.36) | PTPN1 | |
| SCHEMBL7189808 | 0.81 | KDM4E (0.37) | PTPN1PTPN6PTPN11 | |
| SCHEMBL7597546 | 0.77 | PTPN1 (0.36) | PTPN1 | |
| SCHEMBL7190920 | 0.76 | PTPN1 (0.57) | PTPN1PTPN2PTPN6PTPN11 | |
| SCHEMBL7189795 | 0.75 | PTPN1 (0.54) | PTPN5PTPN1PTPN2PTPN6PTPN11 | |
| SCHEMBL7558341 | 0.74 | PTPN1 (0.67) | PTPN1PTPN2 | |
| SCHEMBL7597536 | 0.73 | PTPN1 (0.56) | PTPN5PTPN1PTPN2 | |
| SCHEMBL7192726 | 0.70 | PTPN1 (0.48) | PTPN5PTPN1PGK1PGK2PTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6498151-B2 | PROTEIN TYROSINE PHOSPHATASES INHIBITORS, ESPECIALLY AS ANTIDIABETIC AGENTS | MERCK FROSST CANADA & CO. (CA) | 2002-12-24 | — | — | US | claimed |