Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 2/20 | 0.56 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.48 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | F10 | P00742 | 2/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.43 |
| ▸ | CCR2 | P41597 | 8/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7083764 | 0.92 | ABCB11 (0.57) | ABCB11NOD2NOD1MAPTALDH1A1 | |
| SCHEMBL7596035 | 0.89 | NOD2 (0.53) | ABCB11NOD2NOD1MAPTALDH1A1 | |
| SCHEMBL7083180 | 0.89 | ABCB11 (0.52) | ABCB11NOD2NOD1MAPTALDH1A1 | |
| SCHEMBL7598453 | 0.89 | ABCB11 (0.48) | ABCB11NOD2NOD1MAPTALDH1A1 | |
| SCHEMBL7082975 | 0.86 | ABCB11 (0.74) | ABCB11GPR35CCR2 | |
| SCHEMBL7086760 | 0.85 | ABCB11 (0.53) | ABCB11NOD2NOD1MAPTALDH1A1 | |
| SCHEMBL7168310 | 0.83 | ABCB11 (0.53) | ABCB11NOD2NOD1MAPTALDH1A1 | |
| SCHEMBL7087363 | 0.82 | ABCB11 (0.52) | ABCB11NOD2NOD1MAPTALDH1A1 | |
| SCHEMBL7088272 | 0.81 | NOD2 (0.47) | ABCB11NOD2NOD1MAPTALDH1A1 | |
| SCHEMBL7083815 | 0.81 | ABCB11 (0.61) | ABCB11NOD2NOD1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252142-A1 | INDOLE DERIVATIVES AS MCP-1 RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2002-10-30 | — | — | EP | disclosed |
| WO-2001051466-A1 | INDOLE DERIVATIVES AS MCP-1 RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2001-07-19 | — | — | WO | disclosed |