Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7595652 | 0.87 | PDK2 (0.41) | PDK2 | |
| SCHEMBL7600360 | 0.86 | LMNA (0.38) | ALDH1A1SMN1; SMN2LMNAPDK2 | |
| SCHEMBL7600206 | 0.84 | PDK2 (0.39) | LMNAPDK2 | |
| SCHEMBL7599983 | 0.84 | PDK2 (0.37) | ALDH1A1SMN1; SMN2HPGDKMT2AMEN1 | |
| SCHEMBL7595140 | 0.83 | CA12 (0.42) | KMT2AMEN1GAA | |
| SCHEMBL6770912 | 0.81 | MTTP (0.48) | ALDH1A1POLBTDP1 | |
| SCHEMBL7612764 | 0.80 | MAPT (0.38) | ALDH1A1TDP1KMT2AMEN1PDK2 | |
| SCHEMBL7599929 | 0.80 | TP53 (0.39) | SMN1; SMN2HPGDKMT2AMEN1GAA | |
| SCHEMBL7599607 | 0.79 | NPC1 (0.46) | ALDH1A1KDM4ELMNAHPGDKMT2A | |
| SCHEMBL7596021 | 0.79 | HDAC1 (0.45) | ALDH1A1TDP1HPGDKMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255736-A2 | SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | Boehringer Ingelheim Pharma KG (DE) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001047898-A2 | SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-07-05 | — | — | WO | disclosed |