Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 11/20 | 0.75 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.75 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.73 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.61 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2734889 | 0.86 | GRM2 (1.00) | GRM2SLC9A1TDP1PTK2KDM4E | |
| SCHEMBL28345673 | 0.83 | GRM2 (0.75) | GRM2SLC9A1TDP1PTK2KDM4E | |
| SCHEMBL22000732 | 0.83 | GRM2 (0.75) | GRM2SLC9A1TDP1PTK2 | |
| SCHEMBL16398499 | 0.83 | GRM2 (0.75) | GRM2SLC9A1TDP1KDM4E | |
| SCHEMBL9303448 | 0.83 | PTK2 (0.72) | GRM2SLC9A1TDP1PTK2DOT1L | |
| SCHEMBL6946472 | 0.83 | TDP1 (0.68) | GRM2SLC9A1TDP1PTK2CYP2C9 | |
| SCHEMBL19911614 | 0.81 | GRM2 (0.66) | GRM2SLC9A1TDP1PTK2KDM4E | |
| SCHEMBL19848739 | 0.81 | GRM2 (0.66) | GRM2SLC9A1TDP1PTK2KDM4E | |
| SCHEMBL16892016 | 0.78 | GRM2 (0.71) | GRM2SLC9A1TDP1PTK2CYP2C9 | |
| SCHEMBL9305191 | 0.78 | GAA (0.66) | GRM2SLC9A1TDP1PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6486142-B2 | A,A-DIFLUOROBENZYLPHOSPHONIC ACID DERIVATIVES | MERCK FROSST CANADA & CO. (CA) | 2002-11-26 | — | — | US | disclosed |
| EP-1244678-A1 | PHOSPHONIC ACID DERIVATIVES AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B (PTP-1B) | MERCK FROSST CANADA INC. (CA) | 2002-10-02 | — | — | EP | disclosed |
| US-20020058644-A1 | Phosphonic acid derivatives as inhibitors of protein tyrosine phosphatase 1B (PTP-1B) | MERCK FROSST CANADA LTD. (CA) | 2002-05-16 | — | — | US | disclosed |
| WO-2001046206-A1 | PHOSPHONIC ACID DERIVATIVES AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B (PTP-1B) | MERCK FROSST CANADA & CO. (CA) | 2001-06-28 | — | — | WO | disclosed |
| US-5374701-A | Crosslinkable polymers of high strength free of structural defects | HAY ALLAN S (CA) | 1994-12-20 | — | — | US | disclosed |
| US-5233046-A | DIARYLACETYLENES, ENAMINES AND ACETYLENIC POLYMERS AND THEIR PRODUCTION | HAY ALLAN S (CA) | 1993-08-03 | — | — | US | disclosed |
| WO-1993009079-A1 | DIARYLACETYLENES, ENAMINES AND ACETYLENIC POLYMERS AND THEIR PRODUCTION | HAY ALAN S (CA) | 1993-05-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020058644-A1 | Phosphonic acid derivatives as inhibitors of protein tyrosine phosphatase 1B (PTP-1B) | PPM1B, PTPRO, PTPA | GRM2 1984/4885SLC9A1 1138/4885TDP1 1362/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.