Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 3/20 | 0.55 |
| ▸ | ICAM1 | P05362 | 3/20 | 0.55 |
| ▸ | ITGAL | P20701 | 3/20 | 0.55 |
| ▸ | HTR1D | P28221 | 2/20 | 0.51 |
| ▸ | HTR2C | P28335 | 2/20 | 0.51 |
| ▸ | HTR1E | P28566 | 2/20 | 0.51 |
| ▸ | HTR2B | P41595 | 2/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | HTR3A | P46098 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.50 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.47 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.47 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5808674 | 0.89 | HTR1D (0.51) | ITGB2ICAM1ITGALHTR1DHTR2C | |
| SCHEMBL13912236 | 0.86 | HTR1D (0.49) | ITGB2ICAM1ITGALHTR1DHTR2C | |
| SCHEMBL19051483 | 0.85 | SLC6A5 (0.53) | ITGB2ICAM1ITGALHTR1DHTR2C | |
| SCHEMBL13897023 | 0.85 | CYP3A4 (0.49) | ITGB2ICAM1ITGALHTR1DHTR2C | |
| SCHEMBL10664287 | 0.85 | CYP3A4 (0.49) | ITGB2ICAM1ITGALHTR1DHTR2C | |
| SCHEMBL27413426 | 0.85 | ITGB2 (0.67) | ITGB2ICAM1ITGALCYP3A4SLC7A5 | |
| SCHEMBL29002721 | 0.85 | HTR1D (0.48) | ITGB2ICAM1ITGALHTR1DHTR2C | |
| SCHEMBL28221477 | 0.84 | HRH3 (0.53) | ITGB2ICAM1ITGALSLC6A5 | |
| SCHEMBL11158707 | 0.84 | ITGB2 (0.58) | ITGB2ICAM1ITGALHTR1DHTR2C | |
| SCHEMBL23901492 | 0.84 | CYP3A4 (0.48) | ITGB2ICAM1ITGALHTR1DHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1266900-A1 | Carbamates of rapamycin | Wyeth (US) | 2002-12-18 | — | — | EP | disclosed |
| US-5411967-A | Antiinflammatory, immunosuppressant, antitumor | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-05-02 | — | — | US | disclosed |
| EP-0593227-A1 | Carbamates of rapamycin | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-04-20 | — | — | EP | disclosed |
| US-5302584-A | Immunosuppressants | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-04-12 | — | — | US | disclosed |