Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 3/20 | 0.58 |
| ▸ | ICAM1 | P05362 | 3/20 | 0.58 |
| ▸ | ITGAL | P20701 | 3/20 | 0.58 |
| ▸ | CA1 | P00915 | 2/20 | 0.57 |
| ▸ | CA2 | P00918 | 2/20 | 0.57 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.55 |
| ▸ | HTR1D | P28221 | 2/20 | 0.53 |
| ▸ | HTR2C | P28335 | 2/20 | 0.53 |
| ▸ | HTR1E | P28566 | 2/20 | 0.53 |
| ▸ | HTR2B | P41595 | 2/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | HTR3A | P46098 | 1/20 | 0.53 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | PDE5A | O76074 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL94828 | 0.88 | CA1 (0.55) | ITGB2ICAM1ITGALCA1CA2 | |
| SCHEMBL4525493 | 0.87 | CA1 (0.72) | ITGB2ICAM1ITGALCA1CA2 | |
| SCHEMBL7598348 | 0.84 | ITGB2 (0.55) | ITGB2ICAM1ITGALCA1CA2 | |
| SCHEMBL28287154 | 0.84 | CA1 (0.54) | ITGB2ICAM1ITGALCA1CA2 | |
| SCHEMBL9875941 | 0.82 | MME (0.59) | HTR1DHTR2CHTR1EHTR2BHTR2A | |
| SCHEMBL4070765 | 0.82 | AGTR2 (0.54) | ITGB2ICAM1ITGALCA1CA2 | |
| SCHEMBL5808674 | 0.82 | HTR1D (0.51) | ITGB2ICAM1ITGALHTR1DHTR2C | |
| SCHEMBL9830757 | 0.81 | CA2 (0.67) | ITGB2ICAM1ITGALCA1CA2 | |
| SCHEMBL14046801 | 0.81 | L3MBTL1 (0.57) | ITGB2ICAM1ITGALHTR1DHTR2C | |
| SCHEMBL27342814 | 0.81 | REN (0.56) | ITGB2ICAM1ITGALAGTR2HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4388466-A | HISTIDINE DECARBOXYLASE INHIBITORS | MERRELL TORAUDE ET COMPAGNIE (FR) | 1983-06-14 | — | — | US | disclosed |
| US-4315095-A | ANTIHISTAMINES | MERRELL TORAUDE ET COMPAGNIE (FR) | 1982-02-09 | — | — | US | disclosed |
| US-4103089-A | ANTIHISTAMINES | MERRELL TORAUDE ET COMPAGNIE (FR) | 1978-07-25 | — | — | US | disclosed |
| US-4100349-A | ANTIHISTAMINES | METCALF BRIAN WALTER | 1978-07-11 | — | — | US | disclosed |