Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.47 |
| ▸ | GABRP | O00591 | 2/20 | 0.47 |
| ▸ | GABRD | O14764 | 2/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.47 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.47 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.47 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.47 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.47 |
| ▸ | GABRE | P78334 | 2/20 | 0.47 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.47 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.47 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.47 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31276895 | 1.00 | KMT2A (0.52) | KMT2AHTTHCAR2GABRPGABRD | |
| SCHEMBL186549 | 1.00 | KMT2A (0.52) | KMT2AHTTHCAR2GABRPGABRD | |
| SCHEMBL7334778 | 0.87 | KDM4E (0.50) | KMT2AHTTGABRA5POLBKDM4E | |
| SCHEMBL5904298 | 0.84 | HTT (0.52) | KMT2AHTTMAP4K4HDAC1HDAC6 | |
| SCHEMBL487368 | 0.83 | HCAR2 (0.50) | KMT2AHCAR2GABRPGABRDGABRA1 | |
| SCHEMBL30792836 | 0.83 | HCAR2 (0.50) | KMT2AHCAR2GABRPGABRDGABRA1 | |
| SCHEMBL441934 | 0.82 | HTT (0.50) | KMT2AHTTGABRPGABRDGABRA1 | |
| SCHEMBL10386997 | 0.82 | HTT (0.50) | KMT2AHTTGABRPGABRDGABRA1 | |
| SCHEMBL8806697 | 0.81 | HTT (0.48) | KMT2AHTTGABRPGABRDGABRA1 | |
| SCHEMBL31386903 | 0.80 | GABRP (0.52) | KMT2AHCAR2GABRPGABRDGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915876-A1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | American Cyanamid Company (US) | 1999-05-19 | — | — | EP | disclosed |
| WO-1997049707-A1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID COMPANY (US) | 1997-12-31 | — | — | WO | disclosed |
| EP-0804438-A1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | American Cyanamid Company (US) | 1997-11-05 | — | — | EP | disclosed |