SCHEMBL186549

SCHEMBL186549

Nc1ncc(C(=O)O)cc1Br

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.52
HTT P42858 2/20 0.52
HCAR2 Q8TDS4 4/20 0.47
GABRP O00591 2/20 0.47
GABRD O14764 2/20 0.47
GABRA1 P14867 2/20 0.47
GABRB1 P18505 2/20 0.47
GABRG2 P18507 2/20 0.47
GABRB3 P28472 2/20 0.47
GABRA5 P31644 2/20 0.47
GABRA3 P34903 2/20 0.47
GABRA2 P47869 2/20 0.47
GABRB2 P47870 2/20 0.47
GABRA4 P48169 2/20 0.47
GABRE P78334 2/20 0.47
GABRA6 Q16445 2/20 0.47
GABRG1 Q8N1C3 2/20 0.47
GABRG3 Q99928 2/20 0.47
GABRQ Q9UN88 2/20 0.47
POLB P06746 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7599288 1.00 KMT2A (0.52) KMT2AHTTHCAR2GABRPGABRD
SCHEMBL31276895 1.00 KMT2A (0.52) KMT2AHTTHCAR2GABRPGABRD
SCHEMBL7334778 0.87 KDM4E (0.50) KMT2AHTTGABRA5POLBKDM4E
SCHEMBL5904298 0.84 HTT (0.52) KMT2AHTTMAP4K4HDAC1HDAC6
SCHEMBL487368 0.83 HCAR2 (0.50) KMT2AHCAR2GABRPGABRDGABRA1
SCHEMBL30792836 0.83 HCAR2 (0.50) KMT2AHCAR2GABRPGABRDGABRA1
SCHEMBL441934 0.82 HTT (0.50) KMT2AHTTGABRPGABRDGABRA1
SCHEMBL10386997 0.82 HTT (0.50) KMT2AHTTGABRPGABRDGABRA1
SCHEMBL8806697 0.81 HTT (0.48) KMT2AHTTGABRPGABRDGABRA1
SCHEMBL31386903 0.80 GABRP (0.52) KMT2AHCAR2GABRPGABRDGABRA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119081170-A Fiber reinforced composite material photovoltaic module frame and preparation method thereof 江苏东鋆光伏科技有限公司 2024-12-06 CN claimed
CN-119081170-A Fiber reinforced composite material photovoltaic module frame and preparation method thereof 江苏东鋆光伏科技有限公司 2024-12-06 CN disclosed
EP-3887372-B1 FURTHER HETEROAROMATIC COMPOUNDS HAVING ACTIVITY AGAINST RSV JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) 2022-10-12 EP disclosed
US-20220033396-A1 FURTHER HETEROAROMATIC COMPOUNDS HAVING ACTIVITY AGAINST RSV Janssen Sciences Ireland Unlimited Company (IE) 2022-02-03 US disclosed
EP-3887372-A1 FURTHER HETEROAROMATIC COMPOUNDS HAVING ACTIVITY AGAINST RSV Janssen Sciences Ireland Unlimited Company (IE) 2021-10-06 EP disclosed
CN-113166146-A Other heteroaromatic compounds with anti-RSV activity 爱尔兰詹森科学公司 2021-07-23 CN disclosed
US-20210139507-A1 FUSED PYRIDINES WHICH ACT AS INHIBITORS OF H PGDS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2021-05-13 US disclosed
EP-3724197-A1 FUSED PYRIDINES WHICH ACT AS INHIBITORS OF H-PGDS GlaxoSmithKline Intellectual Property Development Ltd (GB) 2020-10-21 EP disclosed
CN-111479814-A Fused pyridines as H-PGDS inhibitors 葛兰素史密斯克莱知识产权发展有限公司 2020-07-31 CN disclosed
WO-2020109224-A1 FURTHER HETEROAROMATIC COMPOUNDS HAVING ACTIVITY AGAINST RSV Janssen Sciences Ireland Unlimited Company (IE) 2020-06-04 WO disclosed
US-5612334-A Tricyclic benzazepine vasopressin antagonists AMERICAN CYANAMID COMPANY (US) 1997-03-18 US disclosed
US-5610156-A USED IN TREATING DISEASES CHARACTERIZED BY EXCESS RENAL REABSORPTION OF WATER AMERICAN CYANAMID COMPANY (US) 1997-03-11 US disclosed
WO-1996022295-A9 TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS 1996-11-14 WO disclosed
WO-1996022293-A1 TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS AMERICAN CYANAMID COMPANY (US) 1996-07-25 WO disclosed
WO-1996022282-A1 TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS AMERICAN CYANAMID COMPANY (US) 1996-07-25 WO disclosed
WO-1996022294-A1 BICYCLIC BENZAZEPINE DERIVATIVES AS VASOPRESSIN ANTAGONISTS AMERICAN CYANAMID COMPANY (US) 1996-07-25 WO disclosed
WO-1996022295-A1 TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS AMERICAN CYANAMID COMPANY (US) 1996-07-25 WO disclosed
US-5536718-A Tricyclic benzazepine vasopressin antagonists AMERICAN CYANAMID COMPANY (US) 1996-07-16 US disclosed
US-5532235-A TO TREAT EXCESS RENAL REABSORPTION AMERICAN CYANAMID COMPANY (US) 1996-07-02 US disclosed
US-4895950-A 5-halogeno-6-amino-nicotinic acid halides BAYER AKTIENGESELLSCHAFT (DE) 1990-01-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220033396-A1 FURTHER HETEROAROMATIC COMPOUNDS HAVING ACTIVITY AGAINST RSV VIM, MAVS, VARS1 KMT2A 3002/4885HTT 1872/4885HCAR2 3726/4885
US-20210139507-A1 FUSED PYRIDINES WHICH ACT AS INHIBITORS OF H PGDS HPGDS, HPGD, PTGS1 KMT2A 3085/4885HTT 1017/4885HCAR2 636/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.