Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 16/20 | 0.65 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.52 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7599624 | 0.99 | ALOX5 (0.66) | ALOX5GPBAR1ALOX5APHDAC6 | |
| SCHEMBL7599641 | 0.90 | ALOX5 (0.55) | ALOX5GPBAR1ALOX5AP | |
| SCHEMBL7594537 | 0.85 | ALOX5 (0.72) | ALOX5GPBAR1HDAC6 | |
| SCHEMBL7594855 | 0.84 | ALOX5 (0.73) | ALOX5GPBAR1HDAC6 | |
| SCHEMBL8690534 | 0.83 | ALOX5 (0.54) | ALOX5GPBAR1ALOX5APHDAC6 | |
| SCHEMBL8555093 | 0.82 | ALOX5 (0.71) | ALOX5GPBAR1HDAC6 | |
| SCHEMBL8688835 | 0.82 | ALOX5 (0.54) | ALOX5GPBAR1ALOX5APHDAC6 | |
| SCHEMBL8890266 | 0.82 | ALOX5 (0.67) | ALOX5GPBAR1 | |
| SCHEMBL8555241 | 0.81 | ALOX5 (0.72) | ALOX5GPBAR1HDAC6 | |
| SCHEMBL7599636 | 0.81 | ALOX5 (0.55) | ALOX5GPBAR1ALOX5APHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0862557-B1 | SYMMETRICAL bis-HETEROARYLMETHOXYPHENYLALKYL CARBOXYLATES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LAB (US) | 2002-11-27 | — | — | EP | claimed |
| US-5795900-A | Symmetrical bis-heteroaryl-methoxy-phenylalkyl carboxylates as inhibitors of leukotriene biosynthesis | ABBOTT LABORATORIES (US) | 1998-08-18 | — | — | US | claimed |
| EP-0862557-B1 | SYMMETRICAL bis-HETEROARYLMETHOXYPHENYLALKYL CARBOXYLATES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LAB (US) | 2002-11-27 | — | — | EP | disclosed |