Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 17/20 | 0.71 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.55 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8555241 | 0.99 | ALOX5 (0.72) | ALOX5GPBAR1HDAC6CYSLTR2CYSLTR1 | |
| SCHEMBL8552926 | 0.87 | ALOX5 (0.55) | ALOX5CYSLTR2CYSLTR1 | |
| SCHEMBL7594537 | 0.86 | ALOX5 (0.72) | ALOX5GPBAR1HDAC6CYSLTR2CYSLTR1 | |
| SCHEMBL8554150 | 0.86 | ALOX5 (0.61) | ALOX5GPBAR1CYSLTR2CYSLTR1 | |
| SCHEMBL8557403 | 0.85 | ALOX5 (0.56) | ALOX5CYSLTR2CYSLTR1 | |
| SCHEMBL7594855 | 0.85 | ALOX5 (0.73) | ALOX5GPBAR1HDAC6CYSLTR2CYSLTR1 | |
| SCHEMBL8557912 | 0.85 | ALOX5 (0.55) | ALOX5CYSLTR2CYSLTR1 | |
| SCHEMBL8890266 | 0.83 | ALOX5 (0.67) | ALOX5GPBAR1CYSLTR2CYSLTR1 | |
| SCHEMBL7599646 | 0.82 | ALOX5 (0.65) | ALOX5GPBAR1HDAC6 | |
| SCHEMBL8890694 | 0.81 | ALOX5 (0.68) | ALOX5GPBAR1CYSLTR2CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5714488-A | FOR TREATMENT OF ALLERGIC AND INFLAMMATORY DISEASE STATES | ABBOTT LABORATORIES (US) | 1998-02-03 | — | — | US | disclosed |
| WO-1997012866-A1 | BIS-HETEROARYLYLMETHOXYPHENYLKETONE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LABORATORIES (US) | 1997-04-10 | — | — | WO | disclosed |