Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 13/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.51 |
| ▸ | PLK4 | O00444 | 3/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.51 |
| ▸ | PRKCG | P05129 | 3/20 | 0.51 |
| ▸ | CDK1 | P06493 | 3/20 | 0.51 |
| ▸ | PRKACA | P17612 | 3/20 | 0.51 |
| ▸ | CDK2 | P24941 | 3/20 | 0.51 |
| ▸ | MARK3 | P27448 | 3/20 | 0.51 |
| ▸ | AKT2 | P31751 | 3/20 | 0.51 |
| ▸ | FLT4 | P35916 | 3/20 | 0.51 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.51 |
| ▸ | GSK3A | P49840 | 3/20 | 0.51 |
| ▸ | GSK3B | P49841 | 3/20 | 0.51 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.51 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.51 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10269404 | 0.74 | MAPKAPK2 (0.60) | MAPKAPK2ROCK2PLK4MAPK13PDPK1 | |
| SCHEMBL10269106 | 0.73 | MAPKAPK2 (0.51) | MAPKAPK2ROCK2PLK4MAPK13PDPK1 | |
| SCHEMBL10213401 | 0.73 | MAPKAPK2 (0.53) | MAPKAPK2ROCK2PLK4MAPK13PDPK1 | |
| SCHEMBL10213397 | 0.73 | MAPKAPK2 (0.59) | MAPKAPK2ROCK2PLK4MAPK13PDPK1 | |
| SCHEMBL12393059 | 0.73 | MAPKAPK2 (0.55) | MAPKAPK2ROCK2PLK4MAPK13PDPK1 | |
| SCHEMBL10213410 | 0.72 | MAPKAPK2 (0.55) | MAPKAPK2ROCK2PLK4MAPK13PDPK1 | |
| SCHEMBL10213533 | 0.71 | MAPKAPK2 (0.60) | MAPKAPK2ROCK2PLK4MAPK13PDPK1 | |
| SCHEMBL10213448 | 0.71 | MAPKAPK2 (0.49) | MAPKAPK2ROCK2PLK4MAPK13PDPK1 | |
| SCHEMBL758237 | 0.71 | MAPKAPK2 (0.52) | MAPKAPK2ROCK2PLK4MAPK13PDPK1 | |
| SCHEMBL10213524 | 0.71 | MAPKAPK2 (0.52) | MAPKAPK2ROCK2PLK4MAPK13PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120053345-A1 | Indazole Compounds | ABBOTT LABORATORIES (US) | 2012-03-01 | — | — | US | disclosed |
| US-8008481-B2 | Indazole compounds | ABBVIE INC. | 2011-08-30 | — | — | US | disclosed |
| US-20070282101-A1 | Indazole compounds | ABBVIE INC. | 2007-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070282101-A1 | Indazole compounds | CYP3A43, CYP3A7, UGT1A1 | MAPKAPK2 1905/4885ROCK2 3219/4885PLK4 1716/4885 |
| US-20120053345-A1 | Indazole Compounds | CYP3A43, CYP3A7, UGT1A1 | MAPKAPK2 1905/4885ROCK2 3219/4885PLK4 1716/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.