Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | BTK | Q06187 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.55 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.55 |
| ▸ | ACKR3 | P25106 | 6/20 | 0.54 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10702311 | 0.99 | KDM4E (0.67) | KDM4EALDH1A1CYP2D6CYP2C9HIF1A | |
| SCHEMBL17754101 | 0.86 | SMN1; SMN2 (0.63) | ALDH1A1HIF1ABTKMEN1TSHR | |
| SCHEMBL30577399 | 0.86 | SMN1; SMN2 (0.63) | ALDH1A1HIF1ABTKMEN1TSHR | |
| SCHEMBL11926135 | 0.86 | CHRM3 (0.69) | KDM4EALDH1A1BTKMEN1TSHR | |
| SCHEMBL10551915 | 0.86 | HTR1A (0.58) | KDM4EALDH1A1KMT2APOLBGAA | |
| SCHEMBL10556103 | 0.86 | HTR1A (0.58) | KDM4EALDH1A1KMT2APOLBGAA | |
| SCHEMBL10552188 | 0.84 | HTR1A (0.59) | KDM4EALDH1A1BTKKMT2APOLB | |
| SCHEMBL10515943 | 0.84 | CDK5 (0.56) | ALDH1A1CYP2D6CYP2C9HIF1APOLB | |
| SCHEMBL14190849 | 0.84 | KCNH2 (0.55) | BTKMEN1TSHRKMT2AACKR3 | |
| SCHEMBL15156423 | 0.82 | KDM4E (1.00) | KDM4EALDH1A1MEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1137412-A4 | SUBSTITUTED NITROGEN HETEROCYCLIC COMPOUNDS AND THERAPEUTIC USES THEREOF | AMERICAN BIOGENETIC SCIENCES (US) | 2002-04-03 | — | — | EP | disclosed |
| EP-1137412-A2 | SUBSTITUTED NITROGEN HETEROCYCLIC COMPOUNDS AND THERAPEUTIC USES THEREOF | AMERICAN BIOGENETIC SCIENCES, INC. (US) | 2001-10-04 | — | — | EP | disclosed |
| WO-2000033788-A2 | SUBSTITUTED NITROGEN HETEROCYCLIC COMPOUNDS AND THERAPEUTIC USES THEREOF | AMERICAN BIOGENETIC SCIENCES INC. (US) | 2000-06-15 | — | — | WO | disclosed |