Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 6/20 | 0.48 |
| ▸ | CCR3 | P51677 | 6/20 | 0.45 |
| ▸ | FPR2 | P25090 | 2/20 | 0.43 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 9/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 9/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6402580 | 0.81 | HRH1 (0.48) | HRH1CCR3FPR2PROKR1KCNH2 | |
| SCHEMBL7604161 | 0.77 | HRH1 (0.58) | HRH1CCR3FPR2PROKR1TLR8 | |
| SCHEMBL6397887 | 0.77 | HRH1 (0.46) | HRH1CCR3FPR2PROKR1KCNH2 | |
| Ammonia Solution, Strong SCHEMBL6398869 | 0.76 | HRH1 (0.45) | HRH1CCR3FPR2PROKR1KCNH2 | |
| SCHEMBL5102799 | 0.74 | HRH1 (0.59) | HRH1CCR3FPR2PROKR1KCNH2 | |
| SCHEMBL6312412 | 0.72 | MEN1 (0.46) | HRH1CCR3KDM4E | |
| SCHEMBL7518021 | 0.72 | HRH1 (0.57) | HRH1CCR3FPR2PROKR1KCNH2 | |
| SCHEMBL5363961 | 0.72 | CCR3 (0.59) | HRH1CCR3KCNH2 | |
| SCHEMBL5102629 | 0.72 | HRH1 (0.61) | HRH1CCR3KCNH2KDM4E | |
| SCHEMBL5369447 | 0.71 | HRH1 (0.56) | HRH1CCR3FPR2PROKR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165545-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000058305-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2000-10-05 | — | — | WO | disclosed |