Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | HTR1E | P28566 | 2/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | C3AR1 | Q16581 | 3/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7602080 | 0.90 | PTGES (0.43) | PTGESKMT2APGRMEN1LMNA | |
| SCHEMBL13660747 | 0.89 | PTGES (0.51) | PTGESKMT2APGRMEN1LMNA | |
| SCHEMBL7601830 | 0.88 | PTGES (0.46) | PTGESKMT2APGRMEN1LMNA | |
| SCHEMBL7601831 | 0.88 | PTGES (0.46) | PTGESKMT2APGRMEN1LMNA | |
| SCHEMBL7601815 | 0.84 | KMT2A (0.44) | PTGESKMT2APGRMEN1LMNA | |
| SCHEMBL7606055 | 0.82 | KMT2A (0.43) | PTGESKMT2APGRMEN1LMNA | |
| SCHEMBL7606114 | 0.82 | SMN1; SMN2 (0.44) | PTGESKMT2APGRMEN1LMNA | |
| SCHEMBL7601944 | 0.82 | KMT2A (0.42) | PTGESKMT2APGRMEN1LMNA | |
| SCHEMBL12872074 | 0.81 | PTGES (0.43) | PTGESKMT2APGRMEN1LMNA | |
| SCHEMBL1079129 | 0.81 | PTGES (0.60) | PTGESKMT2AMEN1LMNAHTR1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268625-B1 | OXO-HETEROCYCLIC SUBSTITUTED CARBOXYLIC ACID DERIVATES AND THE USE THEREOF | Bayer Pharma AG (DE) | 2012-05-16 | — | — | EP | disclosed |