Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | HTR1E | P28566 | 3/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7601086 | 0.88 | PTGES (0.54) | PTGESKMT2APGRHTR1ES1PR3 | |
| SCHEMBL7601831 | 0.86 | PTGES (0.46) | PTGESKMT2APGRHTR1ES1PR3 | |
| SCHEMBL7601944 | 0.84 | KMT2A (0.42) | PTGESKMT2APGRHTR1ES1PR3 | |
| SCHEMBL13660747 | 0.83 | PTGES (0.51) | PTGESKMT2APGRHTR1ES1PR3 | |
| SCHEMBL7606055 | 0.82 | KMT2A (0.43) | PTGESKMT2APGRHTR1ES1PR3 | |
| SCHEMBL7601815 | 0.82 | KMT2A (0.44) | PTGESKMT2APGRHTR1ES1PR3 | |
| SCHEMBL1178961 | 0.81 | PTGES (0.46) | PTGESKMT2AHTR1ES1PR3LMNA | |
| SCHEMBL1177715 | 0.80 | PTGES (0.44) | PTGESKMT2AHTR1ES1PR3LMNA | |
| SCHEMBL7601328 | 0.79 | KMT2A (0.44) | PTGESKMT2APGRHTR1ES1PR3 | |
| SCHEMBL7602080 | 0.78 | PTGES (0.43) | PTGESKMT2APGRLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268625-B1 | OXO-HETEROCYCLIC SUBSTITUTED CARBOXYLIC ACID DERIVATES AND THE USE THEREOF | Bayer Pharma AG (DE) | 2012-05-16 | — | — | EP | disclosed |