Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.63 |
| ▸ | DRD3 | P35462 | 4/20 | 0.63 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | DRD4 | P21917 | 3/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11398911 | 0.83 | KDM4E (0.62) | DRD2DRD3KDM4EALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL5809774 | 0.82 | DRD2 (0.65) | DRD2DRD3ADRA1ADRD4SLC6A2 | |
| SCHEMBL8957745 | 0.80 | DRD2 (0.60) | DRD2DRD3ADRA1ADRD4 | |
| SCHEMBL3162960 | 0.80 | DRD2 (0.76) | DRD2DRD3DRD4SLC6A2SLC6A4 | |
| SCHEMBL9652871 | 0.78 | DRD2 (0.98) | DRD2DRD3ADRA1ADRD4 | |
| SCHEMBL5820335 | 0.78 | DRD2 (0.59) | DRD2DRD3ADRA1ADRD4SLC6A2 | |
| SCHEMBL14761584 | 0.77 | DRD2 (0.94) | DRD2DRD3ADRA1ADRD4SLC6A2 | |
| Hydrochloric Acid SCHEMBL5819947 | 0.77 | DRD2 (0.58) | DRD2DRD3ADRA1ADRD4SLC6A2 | |
| SCHEMBL19580052 | 0.77 | DRD2 (0.81) | DRD2DRD3ADRA1ADRD4 | |
| SCHEMBL7869518 | 0.77 | DRD2 (1.00) | DRD2DRD3DRD4SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891344-B1 | ALPHA-1 ADRENERGIC RECEPTOR ANTAGONISTS | SOD CONSEILS RECH APPLIC (FR) | 2002-12-18 | — | — | EP | disclosed |
| US-6300499-B1 | α1-adrenergic receptor antagonists | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2001-10-09 | — | — | US | disclosed |
| EP-0891344-A1 | ALPHA 1-ADRENERGIC RECEPTOR ANTAGONISTS | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997037983-A1 | α1-ADRENERGIC RECEPTOR ANTAGONISTS | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 1997-10-16 | — | — | WO | disclosed |