Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.60 |
| ▸ | DRD3 | P35462 | 6/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.60 |
| ▸ | DRD4 | P21917 | 5/20 | 0.57 |
| ▸ | HTR1A | P08908 | 2/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.57 |
| ▸ | DRD1 | P21728 | 2/20 | 0.57 |
| ▸ | DRD5 | P21918 | 2/20 | 0.57 |
| ▸ | HTR2A | P28223 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7601151 | 0.80 | DRD2 (0.63) | DRD2DRD3ADRA1ADRD4 | |
| SCHEMBL3162960 | 0.78 | DRD2 (0.76) | DRD2DRD3DRD4 | |
| Hydrochloric Acid SCHEMBL5809774 | 0.76 | DRD2 (0.65) | DRD2DRD3ADRA1ADRD4 | |
| SCHEMBL9652871 | 0.76 | DRD2 (0.98) | DRD2DRD3ADRA1ADRD4HTR1A | |
| SCHEMBL14761584 | 0.75 | DRD2 (0.94) | DRD2DRD3ADRA1ADRD4HTR1A | |
| SCHEMBL19580052 | 0.75 | DRD2 (0.81) | DRD2DRD3ADRA1ADRD4HTR1A | |
| SCHEMBL7869518 | 0.74 | DRD2 (1.00) | DRD2DRD3DRD4 | |
| SCHEMBL27966706 | 0.74 | DRD2 (1.00) | DRD2DRD3DRD4 | |
| SCHEMBL7601770 | 0.74 | HTR1D (0.66) | DRD2DRD3ADRA1ADRD4HTR1A | |
| SCHEMBL8980577 | 0.73 | DRD2 (0.75) | DRD2DRD3DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0343961-B1 | Aryl- and heteroaryl piperazinyl carboxamides having central nervous system activity | AMERICAN HOME PROD (US) | 1996-01-10 | — | — | EP | claimed |