Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.70 |
| ▸ | TSHR | P16473 | 1/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.70 |
| ▸ | DRD2 | P14416 | 5/20 | 0.66 |
| ▸ | DRD3 | P35462 | 4/20 | 0.66 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.66 |
| ▸ | HTR1A | P08908 | 1/20 | 0.61 |
| ▸ | DRD4 | P21917 | 1/20 | 0.60 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7598216 | 0.85 | DRD2 (0.67) | DRD2DRD3ADRA1AHTR1ADRD4 | |
| SCHEMBL7596185 | 0.84 | DRD2 (0.66) | DRD2DRD3ADRA1AHTR1ADRD4 | |
| SCHEMBL194768 | 0.83 | TP53 (1.00) | TP53CYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL4876834 | 0.82 | TP53 (0.98) | TP53CYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL3162960 | 0.81 | DRD2 (0.76) | DRD2DRD3DRD4SLC6A2SLC6A4 | |
| SCHEMBL1388371 | 0.80 | DRD3 (0.60) | DRD2DRD3ADRA1AHTR1ADRD4 | |
| SCHEMBL9652871 | 0.79 | DRD2 (0.98) | DRD2DRD3ADRA1AHTR1ADRD4 | |
| SCHEMBL14761584 | 0.78 | DRD2 (0.94) | DRD2DRD3ADRA1AHTR1ADRD4 | |
| SCHEMBL19580052 | 0.78 | DRD2 (0.81) | DRD2DRD3ADRA1AHTR1ADRD4 | |
| Oxalic Acid SCHEMBL5378868 | 0.77 | HTR1A (0.61) | TDP1DRD2DRD3ADRA1AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891344-B1 | ALPHA-1 ADRENERGIC RECEPTOR ANTAGONISTS | SOD CONSEILS RECH APPLIC (FR) | 2002-12-18 | — | — | EP | disclosed |
| US-6300499-B1 | α1-adrenergic receptor antagonists | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2001-10-09 | — | — | US | disclosed |
| EP-0891344-A1 | ALPHA 1-ADRENERGIC RECEPTOR ANTAGONISTS | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997037983-A1 | α1-ADRENERGIC RECEPTOR ANTAGONISTS | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 1997-10-16 | — | — | WO | disclosed |