Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.41 |
| ▸ | BCHE | P06276 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | BACE1 | P56817 | 2/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD5 | P21918 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18986974 | 1.00 | HTR2A (0.42) | HTR2AFUCA1BCHEACHEBACE1 | |
| SCHEMBL12371117 | 1.00 | HTR2A (0.42) | HTR2AFUCA1BCHEACHEBACE1 | |
| SCHEMBL28948610 | 0.84 | FUCA1 (0.41) | HTR2AFUCA1BCHEACHEBACE1 | |
| SCHEMBL26709646 | 0.83 | RECQL (0.48) | HTR2AFUCA1ACHERECQLSMN1; SMN2 | |
| SCHEMBL4193483 | 0.83 | RECQL (0.48) | HTR2AFUCA1ACHERECQLSMN1; SMN2 | |
| SCHEMBL2241410 | 0.83 | FUCA1 (0.45) | HTR2AFUCA1S1PR1S1PR5DRD2 | |
| SCHEMBL13521597 | 0.78 | HTR2A (0.48) | HTR2ABCHEACHEBACE1 | |
| SCHEMBL12347368 | 0.77 | PTPN1 (0.42) | HTR2AFUCA1ACHERECQLSMN1; SMN2 | |
| SCHEMBL25746377 | 0.76 | HTR2A (0.43) | HTR2ABCHEACHEBACE1DRD2 | |
| SCHEMBL11413096 | 0.75 | FUCA1 (0.60) | FUCA1BCHEACHEBACE1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108368112-B | Therapeutic compounds, compositions, and methods of use thereof | 豪夫迈·罗氏有限公司 | 2021-11-02 | — | — | CN | disclosed |
| US-10189836-B2 | Therapeutic compounds, compositions and methods of use thereof | GENENTECH, INC. (US) | 2019-01-29 | — | — | US | disclosed |
| EP-3390402-A1 | THERAPEUTIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | H. Hoffnabb-La Roche Ag (CH) | 2018-10-24 | — | — | EP | disclosed |
| US-20180297997-A1 | THERAPEUTIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-10-18 | — | — | US | disclosed |
| WO-2017103188-A1 | THERAPEUTIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2017-06-22 | — | — | WO | disclosed |
| EP-2050745-B1 | N-PYRIDYLPIPERIDINE COMPOUND, METHOD FOR PRODUCING THE SAME, AND PEST CONTROL AGENT | OTSUKA AGRITECHNO CO LTD (JP) | 2012-03-21 | — | — | EP | disclosed |
| US-7994094-B2 | N-pyridylpiperidine compound, method for producing the same, and pest control agent | OTSUKA AGRITECHNO CO., LTD. (JP) | 2011-08-09 | — | — | US | disclosed |
| US-20100137582-A1 | N-PYRIDYLPIPERIDINE COMPOUND, METHOD FOR PRODUCING THE SAME, AND PEST CONTROL AGENT | OTSUKA CHEMICAL CO., LTD. (JP) | 2010-06-03 | — | — | US | disclosed |
| EP-2050745-A1 | N-PYRIDYLPIPERIDINE COMPOUND, METHOD FOR PRODUCING THE SAME, AND PEST CONTROL AGENT | Otsuka Chemical Co., Ltd. (JP) | 2009-04-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10189836-B2 | Therapeutic compounds, compositions and methods of use thereof | JAK2, JAK1, JAK3 | HTR2A 4607/4885FUCA1 2120/4885BCHE 2882/4885 |
| US-20100137582-A1 | N-PYRIDYLPIPERIDINE COMPOUND, METHOD FOR PRODUCING THE SAME, AND PEST CONTROL AGENT | HRH4, NOX4, PRDX4 | HTR2A 1835/4885FUCA1 4879/4885BCHE 1993/4885 |
| US-20180297997-A1 | THERAPEUTIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | JAK2, JAK1, JAK3 | HTR2A 4607/4885FUCA1 2120/4885BCHE 2882/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.