SCHEMBL7602824

SCHEMBL7602824

CC(C)(C)Nc1c(NCc2ccc(Cl)cc2Cl)c(=O)c1=O

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ROCK2 O75116 2/20 0.49
CHEK2 O96017 2/20 0.49
PRKACA P17612 2/20 0.49
RPS6KA3 P51812 2/20 0.49
PAK1 Q13153 2/20 0.49
ROCK1 Q13464 2/20 0.49
DYRK1A Q13627 2/20 0.49
PRKD2 Q9BZL6 2/20 0.49
IRAK4 Q9NWZ3 2/20 0.49
JAK2 O60674 1/20 0.49
GSK3A P49840 1/20 0.49
PRKCD Q05655 1/20 0.49
PRKAA1 Q13131 1/20 0.49
CDC42BPA Q5VT25 1/20 0.49
AURKB Q96GD4 1/20 0.49
DCLK1 O15075 1/20 0.45
PRKD3 O94806 1/20 0.45
MAP4K4 O95819 1/20 0.45
PHKG2 P15735 1/20 0.45
AKT2 P31751 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7894102 0.89 CHEK2 (0.39) ROCK2CHEK2PRKACARPS6KA3PAK1
SCHEMBL7596888 0.88 ROCK2 (0.47) ROCK2CHEK2PRKACARPS6KA3PAK1
SCHEMBL7601302 0.87 ROCK2 (0.46) ROCK2CHEK2PRKACARPS6KA3PAK1
SCHEMBL7895359 0.86 P2RX7 (0.41) ROCK2CHEK2PRKACARPS6KA3PAK1
SCHEMBL4263948 0.84 P2RX7 (0.45) ROCK2CHEK2PRKACARPS6KA3PAK1
SCHEMBL7597380 0.81 ROCK2 (0.46) ROCK2CHEK2PRKACARPS6KA3PAK1
SCHEMBL7600179 0.81 ROCK2 (0.46) ROCK2CHEK2PRKACARPS6KA3PAK1
SCHEMBL7597329 0.81 ROCK2 (0.46) ROCK2CHEK2PRKACARPS6KA3PAK1
SCHEMBL7597830 0.78 IRAK4 (0.47) ROCK2CHEK2PRKACARPS6KA3PAK1
SCHEMBL7887060 0.78 HDAC3 (0.42) ROCK2CHEK2PRKACARPS6KA3PAK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0934257-B1 SUBSTITUTED N-ARYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES WYETH CORP (US) 2002-12-11 EP claimed
EP-1151990-A1 Substituted N-arylmethylamino derivatives of cyclobutene-3, 4-diones AMERICAN HOME PRODUCTS CORPORATION (US) 2001-11-07 EP claimed
EP-0934257-A1 SUBSTITUTED N-ARYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES AMERICAN HOME PRODUCTS CORPORATION (US) 1999-08-11 EP claimed
US-5763474-A SMOOTH MUSCLE RELAXANTS AMERICAN HOME PRODUCTS CORPORATION (US) 1998-06-09 US claimed
WO-1998002413-A1 SUBSTITUTED N-ARYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES AMERICAN HOME PRODUCTS CORPORATION (US) 1998-01-22 WO claimed
EP-0934257-B1 SUBSTITUTED N-ARYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES WYETH CORP (US) 2002-12-11 EP disclosed
EP-1151990-A1 Substituted N-arylmethylamino derivatives of cyclobutene-3, 4-diones AMERICAN HOME PRODUCTS CORPORATION (US) 2001-11-07 EP disclosed
EP-0934257-A1 SUBSTITUTED N-ARYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES AMERICAN HOME PRODUCTS CORPORATION (US) 1999-08-11 EP disclosed
US-5763474-A SMOOTH MUSCLE RELAXANTS AMERICAN HOME PRODUCTS CORPORATION (US) 1998-06-09 US disclosed
WO-1998002413-A1 SUBSTITUTED N-ARYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES AMERICAN HOME PRODUCTS CORPORATION (US) 1998-01-22 WO disclosed