Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | CDK1 | P06493 | 2/20 | 0.48 |
| ▸ | BRD4 | O60885 | 9/20 | 0.47 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | JAK1 | P23458 | 2/20 | 0.46 |
| ▸ | JAK3 | P52333 | 2/20 | 0.46 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.45 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | ULK1 | O75385 | 2/20 | 0.43 |
| ▸ | ULK2 | Q8IYT8 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL264267 | 0.91 | BRD4 (0.51) | CDK1BRD4JAK2CYP3A4JAK1 | |
| SCHEMBL270949 | 0.88 | BRD4 (0.49) | BRD4STK17AAXL | |
| SCHEMBL271507 | 0.85 | BRD4 (0.62) | KDRBRD4JAK2CYP3A4JAK1 | |
| SCHEMBL271520 | 0.82 | AURKA (0.51) | CDK2KDRBRD4JAK2JAK1 | |
| SCHEMBL265703 | 0.80 | BRD4 (0.63) | KDRBRD4JAK2CYP3A4JAK1 | |
| SCHEMBL271306 | 0.79 | JAK2 (0.56) | BRD4JAK2CYP3A4JAK1JAK3 | |
| SCHEMBL270995 | 0.79 | BRD4 (0.61) | CDK2KDRCDK1BRD4JAK2 | |
| SCHEMBL266088 | 0.79 | BRD4 (0.56) | BRD4STK17AAXL | |
| SCHEMBL271021 | 0.79 | SYK (0.68) | CDK2KDRCDK1BRD4JAK2 | |
| SCHEMBL17915945 | 0.79 | RAPGEF4 (0.52) | KDRBRD4JAK2CYP3A4JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138199-B2 | Use of bi-aryl meta-pyrimidine inhibitors of kinases | TARGEGEN, INC. (US) | 2012-03-20 | — | — | US | disclosed |