Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13100724 | 0.87 | HPGD (0.74) | TDP1LMNAALDH1A1HPGDKMT2A | |
| SCHEMBL16248438 | 0.86 | LMNA (0.61) | TDP1LMNAALDH1A1HPGDKMT2A | |
| SCHEMBL9309788 | 0.86 | TDP1 (0.59) | TDP1LMNAALDH1A1HPGDKMT2A | |
| SCHEMBL1526930 | 0.86 | TDP1 (0.59) | TDP1LMNAALDH1A1HPGDKMT2A | |
| SCHEMBL7185156 | 0.85 | LMNA (0.60) | TDP1LMNAALDH1A1HPGDKMT2A | |
| SCHEMBL28554560 | 0.84 | TDP1 (0.58) | TDP1LMNAALDH1A1HPGDKMT2A | |
| SCHEMBL6408925 | 0.83 | TDP1 (0.56) | TDP1LMNAALDH1A1HPGDKMT2A | |
| SCHEMBL28322559 | 0.83 | LMNA (0.62) | TDP1LMNAALDH1A1HPGDKMT2A | |
| SCHEMBL18972439 | 0.82 | POLB (0.71) | LMNAALDH1A1HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL137486 | 0.82 | TDP1 (0.83) | TDP1LMNAALDH1A1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1266900-A1 | Carbamates of rapamycin | Wyeth (US) | 2002-12-18 | — | — | EP | disclosed |
| EP-0593227-A1 | Carbamates of rapamycin | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-04-20 | — | — | EP | disclosed |
| US-5302584-A | Immunosuppressants | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-04-12 | — | — | US | disclosed |