Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | FPR3 | P25089 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7602628 | 0.97 | FPR3 (0.40) | ALDH1A1LMNASMN1; SMN2KMT2AMAPT | |
| SCHEMBL7599330 | 0.88 | FPR3 (0.41) | ALDH1A1LMNASMN1; SMN2KMT2AMAPT | |
| SCHEMBL6770959 | 0.87 | MTTP (0.45) | ALDH1A1LMNASMN1; SMN2KMT2AMAPT | |
| SCHEMBL7599828 | 0.85 | ALDH1A1 (0.41) | ALDH1A1LMNASMN1; SMN2KMT2AMAPT | |
| SCHEMBL6770036 | 0.85 | MTTP (0.43) | ALDH1A1LMNASMN1; SMN2KMT2AMAPT | |
| SCHEMBL7607955 | 0.84 | NPC1 (0.42) | ALDH1A1LMNASMN1; SMN2KMT2AMAPT | |
| SCHEMBL7602545 | 0.84 | MAPT (0.45) | ALDH1A1LMNASMN1; SMN2KMT2AMAPT | |
| SCHEMBL7608953 | 0.84 | DRD3 (0.38) | — | |
| SCHEMBL7607632 | 0.83 | DRD3 (0.38) | LMNAHTT | |
| SCHEMBL7601733 | 0.83 | DRD3 (0.39) | LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255736-A2 | SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | Boehringer Ingelheim Pharma KG (DE) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001047898-A2 | SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-07-05 | — | — | WO | disclosed |