Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 3/20 | 0.48 |
| ▸ | CASR | P41180 | 3/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.39 |
| ▸ | CYP4F11 | Q9HBI6 | 1/20 | 0.39 |
| ▸ | CYP4F12 | Q9HCS2 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7604094 | 1.00 | MGLL (0.48) | MGLLCASRFFAR1FFAR4KCNH2 | |
| SCHEMBL7604752 | 0.94 | MGLL (0.48) | MGLLCASRKCNH2ADRB2CYP2D6 | |
| SCHEMBL7604748 | 0.94 | MGLL (0.48) | MGLLCASRKCNH2ADRB2CYP2D6 | |
| SCHEMBL7603924 | 0.94 | CASR (0.52) | MGLLCASRFFAR1FFAR4KCNH2 | |
| SCHEMBL7603925 | 0.94 | CASR (0.52) | MGLLCASRFFAR1FFAR4KCNH2 | |
| SCHEMBL6374360 | 0.87 | CASR (0.49) | MGLLCASRKCNH2ADRB2CYP2D6 | |
| SCHEMBL11023521 | 0.83 | MGLL (0.50) | MGLLCYP4Z1CYP4F11CYP4F12 | |
| SCHEMBL3348258 | 0.81 | FFAR1 (0.59) | CASRFFAR1FFAR4 | |
| SCHEMBL3348748 | 0.81 | FFAR1 (0.59) | CASRFFAR1FFAR4 | |
| SCHEMBL3346797 | 0.80 | FFAR1 (0.43) | CASRFFAR1FFAR4KCNH2KCNJ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6395919-B1 | Calcilytic compounds | SMITHKLINE BEECHAM CORPORATION | 2002-05-28 | — | — | US | disclosed |
| EP-1070048-A4 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2001-11-07 | — | — | EP | disclosed |
| EP-1070048-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-01-24 | — | — | EP | disclosed |
| WO-1999051569-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-10-14 | — | — | WO | disclosed |