SCHEMBL7604647

SCHEMBL7604647

CC(C)(C)OC(=O)N(Cc1ccccc1)CC(c1ccc(O)c(Cl)c1)c1ccc(O)c(Cl)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BACE1 P56817 5/20 0.46
HDAC3 O15379 1/20 0.43
HDAC1 Q13547 1/20 0.43
HDAC2 Q92769 1/20 0.43
NCOR2 Q9Y618 1/20 0.43
CTSL P07711 1/20 0.41
CTSB P07858 1/20 0.41
CTSS P25774 1/20 0.41
HSP90AA1 P07900 1/20 0.40
AKT1 P31749 2/20 0.40
LMNA P02545 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
HTT P42858 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
NR1H4 Q96RI1 1/20 0.37
TSHR P16473 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7607698 0.85 BACE1 (0.45) BACE1HDAC3HDAC1HDAC2NCOR2
SCHEMBL7606227 0.83 HDAC3 (0.51) BACE1HDAC3HDAC1HDAC2NCOR2
SCHEMBL8127646 0.77 HDAC1 (0.53) BACE1HDAC3HDAC1HDAC2NCOR2
SCHEMBL24323598 0.76 BACE1 (0.62) BACE1HDAC3HDAC1HDAC2NCOR2
SCHEMBL29059512 0.76 BACE1 (0.62) BACE1HDAC3HDAC1HDAC2NCOR2
SCHEMBL18191672 0.76 HDAC3 (0.55) BACE1HDAC3HDAC1HDAC2NCOR2
SCHEMBL24324611 0.76 HDAC3 (0.52) BACE1HDAC3HDAC1HDAC2NCOR2
SCHEMBL15311357 0.76 HDAC3 (0.52) BACE1HDAC3HDAC1HDAC2NCOR2
SCHEMBL1235983 0.76 HDAC3 (0.52) BACE1HDAC3HDAC1HDAC2NCOR2
SCHEMBL1799264 0.75 BACE1 (0.49) BACE1HDAC3HDAC1HDAC2NCOR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1230210-A1 AMINOALCOHOL DERIVATIVES USEFUL FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2002-08-14 EP disclosed
WO-2001036375-A1 AMINOALCOHOL DERIVATIVES USEFUL FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-05-25 WO disclosed