Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 5/20 | 0.49 |
| ▸ | NR1H3 | Q13133 | 10/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 9/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | VHL | P40337 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.43 |
| ▸ | GLS | O94925 | 1/20 | 0.41 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7606227 | 0.81 | HDAC3 (0.51) | BACE1ALDH1A1RECQLHDAC3HDAC1 | |
| SCHEMBL4128906 | 0.80 | GLS (0.42) | BACE1NR1H3NR1H2RXRAHDAC3 | |
| SCHEMBL14987121 | 0.79 | GLS (0.56) | MEN1KMT2AGLS | |
| SCHEMBL1801153 | 0.79 | HDAC1 (0.47) | BACE1NR1H2MEN1KMT2AHDAC3 | |
| SCHEMBL24323598 | 0.78 | BACE1 (0.62) | BACE1MEN1KMT2AHDAC3HDAC1 | |
| SCHEMBL29059512 | 0.78 | BACE1 (0.62) | BACE1MEN1KMT2AHDAC3HDAC1 | |
| SCHEMBL1799972 | 0.76 | HDAC1 (0.43) | BACE1HDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL8127646 | 0.76 | HDAC1 (0.53) | BACE1ALDH1A1RECQLHDAC3HDAC1 | |
| SCHEMBL19359210 | 0.76 | BACE1 (0.47) | BACE1ALDH1A1MAPTHDAC3HDAC1 | |
| SCHEMBL7604647 | 0.75 | BACE1 (0.46) | BACE1HDAC3HDAC1HDAC2NCOR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951954-B2 | Bezothiazol derivatives as Beta2 adrenoreceptor agonists | ASTRAZENECA AB (SE) | 2011-05-31 | — | — | US | disclosed |
| CN-101443320-A | Benzothiazole derivatives as beta 2 adrenoreceptor agonists | ASTRAZENECA AB (SE) | 2009-05-27 | — | — | CN | disclosed |
| US-20090062259-A1 | Bezothiazol Derivatives as Beta2 Adrenoreceptor Agonists | ASTRAZENECA AB (SE) | 2009-03-05 | — | — | US | disclosed |
| EP-1996566-A1 | BEZOTHIAZOL DERIVATIVES AS BETA2 ADRENORECEPTOR AGONISTS | AstraZeneca AB (SE) | 2008-12-03 | — | — | EP | disclosed |
| WO-2007106016-A1 | BEZOTHIAZOL DERIVATIVES AS BETA2 ADRENORECEPTOR AGONISTS | ASTRAZENECA AB (SE) | 2007-09-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090062259-A1 | Bezothiazol Derivatives as Beta2 Adrenoreceptor Agonists | ADRB2, ADRB1, ADRB3 | BACE1 377/4885NR1H3 104/4885NR1H2 37/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.