Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL978898 | 0.86 | TSHR (0.59) | TSHRTDP1MAPTALDH1A1MEN1 | |
| SCHEMBL28135866 | 0.83 | TSHR (0.53) | TSHRTDP1MAPTALDH1A1MEN1 | |
| SCHEMBL20362349 | 0.83 | TSHR (0.56) | TSHRTDP1MAPTALDH1A1MEN1 | |
| SCHEMBL4136656 | 0.82 | LMNA (0.55) | TSHRTDP1MAPTALDH1A1MEN1 | |
| SCHEMBL11462352 | 0.82 | TSHR (0.51) | TSHRTDP1MAPTALDH1A1MEN1 | |
| SCHEMBL15887336 | 0.82 | TSHR (0.51) | TSHRTDP1MAPTALDH1A1MEN1 | |
| SCHEMBL4434685 | 0.81 | ALDH1A1 (0.53) | TSHRTDP1MAPTALDH1A1MEN1 | |
| SCHEMBL15762737 | 0.81 | EPAS1 (0.48) | TSHRMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL10438572 | 0.80 | TSHR (0.53) | TSHRTDP1MAPTALDH1A1MEN1 | |
| SCHEMBL16654104 | 0.80 | TSHR (0.53) | TSHRTDP1MAPTALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212096-A2 | DRUG CONJUGATES AND METHODS OF DESIGNING THE SAME | Brenner, Sydney (US) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001013958-A2 | DRUG CONJUGATES AND METHODS OF DESIGNING THE SAME | BRENNER SYDNEY (US) | 2001-03-01 | — | — | WO | disclosed |