Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19391819 | 0.82 | KMT2A (0.42) | LMNASMN1; SMN2KMT2ATDP1L3MBTL1 | |
| SCHEMBL16047247 | 0.79 | KMT2A (0.52) | LMNASMN1; SMN2KMT2ATDP1L3MBTL1 | |
| SCHEMBL9965803 | 0.79 | KMT2A (0.46) | LMNASMN1; SMN2KMT2ATDP1TSHR | |
| SCHEMBL1478855 | 0.78 | ESR1 (0.59) | LMNACYP1A2CYP2D6SMN1; SMN2KMT2A | |
| SCHEMBL6662585 | 0.77 | PKM (0.53) | LMNAPKMSMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL7603139 | 0.77 | LMNA (0.53) | LMNACYP1A2CYP2D6PKMSMN1; SMN2 | |
| SCHEMBL10229011 | 0.76 | KMT2A (0.47) | LMNASMN1; SMN2KMT2AL3MBTL1TSHR | |
| SCHEMBL6549496 | 0.76 | IDO1 (0.53) | CYP1A2CYP2D6SMN1; SMN2KMT2ATDP1 | |
| SCHEMBL31131464 | 0.75 | KMT2A (0.49) | LMNASMN1; SMN2NPSR1KMT2ATDP1 | |
| SCHEMBL7909243 | 0.75 | KMT2A (0.49) | LMNASMN1; SMN2NPSR1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1266900-A1 | Carbamates of rapamycin | Wyeth (US) | 2002-12-18 | — | — | EP | disclosed |
| US-5411967-A | Antiinflammatory, immunosuppressant, antitumor | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-05-02 | — | — | US | disclosed |
| EP-0593227-A1 | Carbamates of rapamycin | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-04-20 | — | — | EP | disclosed |
| US-5302584-A | Immunosuppressants | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-04-12 | — | — | US | disclosed |