Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 2/20 | 0.59 |
| ▸ | PTPN1 | P18031 | 11/20 | 0.53 |
| ▸ | EYA3 | Q99504 | 3/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | EYA2 | O00167 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.46 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ALB | P02768 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7605390 | 0.89 | TTR (0.48) | TTRPTPN1EYA3CYP2C19CYP2C9 | |
| SCHEMBL5988290 | 0.84 | PTPN1 (0.51) | TTRPTPN1EYA3 | |
| SCHEMBL7924529 | 0.84 | PTPN1 (0.55) | TTRPTPN1EYA3CYP2C19CYP2C9 | |
| SCHEMBL6734077 | 0.83 | PTPN1 (0.63) | TTRPTPN1EYA3CYP2C9MEN1 | |
| SCHEMBL5988680 | 0.83 | PTPN1 (0.55) | TTRPTPN1THRBNR1H4 | |
| SCHEMBL7816673 | 0.79 | PTPN1 (0.54) | TTRPTPN1EYA3CYP2C19CYP2C9 | |
| SCHEMBL7056364 | 0.78 | PTPN1 (0.46) | TTRPTPN1EYA3CYP2C19CYP2C9 | |
| SCHEMBL7638712 | 0.76 | PTPN1 (0.57) | TTRPTPN1EYA3CYP2C19CYP2C9 | |
| SCHEMBL1287644 | 0.74 | TTR (1.00) | TTRPTPN1EYA3CYP2C19CYP2C9 | |
| SCHEMBL5989086 | 0.74 | PTPN1 (0.56) | PTPN1EYA3ALDH1A1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002516305-A | — | — | 2002-06-04 | — | — | JP | claimed |
| EP-1077929-A1 | 2,3,5-SUBSTITUTED BIPHENYLS USEFUL IN THE TREATMENT OF INSULIN RESISTANCE AND HYPERGLYCEMIA | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-02-28 | — | — | EP | claimed |
| WO-1999061410-A1 | 2,3,5-SUBSTITUTED BIPHENYLS USEFUL IN THE TREATMENT OF INSULIN RESISTANCE AND HYPERGLYCEMIA | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-12-02 | — | — | WO | claimed |
| US-6451827-B2 | MODULATING BLOOD GLUCOSE CONCENTRATION | WYETH | 2002-09-17 | — | — | US | disclosed |