Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 14/20 | 0.55 |
| ▸ | TTR | P02766 | 2/20 | 0.51 |
| ▸ | EYA3 | Q99504 | 3/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | EYA2 | O00167 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.39 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALB | P02768 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7605397 | 0.84 | TTR (0.59) | PTPN1TTREYA3THRBEYA2 | |
| SCHEMBL6734077 | 0.81 | PTPN1 (0.63) | PTPN1TTREYA3MEN1CYP2C9 | |
| SCHEMBL7605390 | 0.80 | TTR (0.48) | PTPN1TTREYA3THRBCYP1A2 | |
| SCHEMBL7816673 | 0.79 | PTPN1 (0.54) | PTPN1TTREYA3MEN1CYP1A2 | |
| SCHEMBL5988290 | 0.76 | PTPN1 (0.51) | PTPN1TTREYA3 | |
| SCHEMBL5988680 | 0.74 | PTPN1 (0.55) | PTPN1TTRTHRBNR1H4SIRT3 | |
| SCHEMBL8810393 | 0.73 | PTPN1 (0.61) | PTPN1TTREYA3THRBTHRA | |
| SCHEMBL7814160 | 0.72 | PTPN1 (0.45) | PTPN1TTREYA3THRBSIRT3 | |
| Hydrochloric Acid SCHEMBL8732680 | 0.72 | PTPN1 (0.60) | PTPN1TTREYA3THRBTHRA | |
| SCHEMBL6735103 | 0.72 | PTPN1 (0.75) | PTPN1TTREYA3CYP2C9NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20010018525-A1 | 2, 3, 5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia | WYETH | 2001-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010018525-A1 | 2, 3, 5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia | INSR, GPR119, IRS1 | PTPN1 1619/4885TTR 2589/4885EYA3 3837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.