Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 11/20 | 0.54 |
| ▸ | EYA3 | Q99504 | 2/20 | 0.47 |
| ▸ | TTR | P02766 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6734077 | 0.82 | PTPN1 (0.63) | PTPN1EYA3TTRMEN1KMT2A | |
| SCHEMBL7924529 | 0.79 | PTPN1 (0.55) | PTPN1EYA3TTRMEN1KMT2A | |
| SCHEMBL7605397 | 0.79 | TTR (0.59) | PTPN1EYA3TTRMEN1KMT2A | |
| SCHEMBL5988290 | 0.77 | PTPN1 (0.51) | PTPN1EYA3TTR | |
| SCHEMBL8810393 | 0.77 | PTPN1 (0.61) | PTPN1EYA3TTR | |
| Hydrochloric Acid SCHEMBL8732680 | 0.76 | PTPN1 (0.60) | PTPN1EYA3TTR | |
| SCHEMBL7605390 | 0.74 | TTR (0.48) | PTPN1EYA3TTRCYP1A2CYP3A4 | |
| SCHEMBL1854853 | 0.74 | PTPN1 (0.58) | PTPN1EYA3TTR | |
| SCHEMBL11218137 | 0.73 | PTPN1 (0.57) | PTPN1EYA3TTR | |
| SCHEMBL7816676 | 0.73 | PTPN1 (0.58) | PTPN1EYA3TTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077929-A1 | 2,3,5-SUBSTITUTED BIPHENYLS USEFUL IN THE TREATMENT OF INSULIN RESISTANCE AND HYPERGLYCEMIA | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999061410-A1 | 2,3,5-SUBSTITUTED BIPHENYLS USEFUL IN THE TREATMENT OF INSULIN RESISTANCE AND HYPERGLYCEMIA | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-12-02 | — | — | WO | disclosed |