Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 2/20 | 0.55 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.55 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.55 |
| ▸ | PDE4A | P27815 | 10/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.50 |
| ▸ | PDE2A | O00408 | 1/20 | 0.48 |
| ▸ | PDE5A | O76074 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CFTR | P13569 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | SCN1A | P35498 | 1/20 | 0.48 |
| ▸ | PDE6C | P51160 | 1/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1200300 | 0.80 | ADORA2A (0.68) | PDE1APDE1BPDE1CPDE4APDE4B | |
| SCHEMBL4471527 | 0.80 | PDE1A (0.67) | PDE1APDE1BPDE1CPDE4APDE4B | |
| SCHEMBL11033822 | 0.79 | PDE1A (0.73) | PDE1APDE1BPDE1CPDE4APDE4B | |
| SCHEMBL11012550 | 0.78 | PDE1A (0.64) | PDE1APDE1BPDE1CPDE4APDE4B | |
| SCHEMBL7089727 | 0.77 | ADORA2B (0.68) | PDE1APDE1BPDE1CPDE4APDE4B | |
| SCHEMBL11004837 | 0.75 | PDE4A (0.73) | PDE1APDE1BPDE1CPDE4APDE4B | |
| SCHEMBL11379486 | 0.74 | PDE1A (0.54) | PDE1APDE1BPDE1CPDE4APDE4B | |
| SCHEMBL11386278 | 0.74 | PDE1A (0.63) | PDE1APDE1BPDE1CPDE4APDE4B | |
| SCHEMBL27378735 | 0.73 | PDE1A (0.65) | PDE1APDE1BPDE1CPDE4APDE4B | |
| SCHEMBL9853395 | 0.72 | PDE4A (0.73) | PDE1APDE1BPDE1CPDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020035117-A1 | Theophylline and 3-isobutyl-1-methylxanthine based N-7 substituted derivatives displaying inhibitory activities on type five phosphodiesterase | CHEN ING-JUN (TW) | 2002-03-21 | — | — | US | claimed |
| US-20020035117-A1 | Theophylline and 3-isobutyl-1-methylxanthine based N-7 substituted derivatives displaying inhibitory activities on type five phosphodiesterase | CHEN ING-JUN (TW) | 2002-03-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020035117-A1 | Theophylline and 3-isobutyl-1-methylxanthine based N-7 substituted derivatives displaying inhibitory activities on type five phosphodiesterase | PDE3A, PDE3B, PDE5A | PDE1A 78/4885PDE1B 83/4885PDE1C 89/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.