SCHEMBL7606264

SCHEMBL7606264

OCc1cc(OC[C@@H](O)CN(Cc2ccccc2)CC(c2ccc(O)cc2)c2ccc(O)cc2)ccc1OCc1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.46
MAPT P10636 2/20 0.46
GAA P10253 1/20 0.46
MAPK1 P28482 1/20 0.46
TSHR P16473 1/20 0.46
POLB P06746 3/20 0.45
ELANE P08246 4/20 0.41
F2 P00734 1/20 0.41
NPC1 O15118 1/20 0.40
BCHE P06276 1/20 0.40
CYP1A2 P05177 2/20 0.39
CYP2C19 P33261 2/20 0.39
CYP2D6 P10635 1/20 0.39
CYP2C9 P11712 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
ABCB1 P08183 1/20 0.39
CTSG P08311 1/20 0.38
MMP1 P03956 1/20 0.38
MMP2 P08253 1/20 0.38
MMP9 P14780 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7605315 0.85 POLB (0.43) ALDH1A1MAPTGAAMAPK1TSHR
SCHEMBL7042722 0.84 ALDH1A1 (0.41) ALDH1A1MAPTGAAMAPK1TSHR
SCHEMBL7608353 0.82 POLB (0.49) ALDH1A1MAPTGAAMAPK1TSHR
SCHEMBL7688756 0.82 POLB (0.64) ALDH1A1MAPTGAAMAPK1TSHR
SCHEMBL7688754 0.82 POLB (0.64) ALDH1A1MAPTGAAMAPK1TSHR
SCHEMBL7042715 0.80 OPRD1 (0.40) ALDH1A1MAPTGAAMAPK1TSHR
SCHEMBL7252017 0.80 BCHE (0.42) ALDH1A1MAPTGAAMAPK1TSHR
SCHEMBL7606888 0.80 ALDH1A1 (0.52) ALDH1A1MAPTGAAMAPK1TSHR
SCHEMBL7690585 0.79 POLB (0.45) ALDH1A1MAPTGAAMAPK1TSHR
SCHEMBL7690582 0.79 POLB (0.45) ALDH1A1MAPTGAAMAPK1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1230210-A1 AMINOALCOHOL DERIVATIVES USEFUL FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2002-08-14 EP disclosed
WO-2001036375-A1 AMINOALCOHOL DERIVATIVES USEFUL FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-05-25 WO disclosed