Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.40 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.40 |
| ▸ | ITGAL | P20701 | 2/20 | 0.40 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 2/20 | 0.34 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.34 |
| ▸ | HTR3B | O95264 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.34 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7610320 | 0.82 | ITGB2 (0.50) | TSHRPOLBGAAITGB2ICAM1 | |
| SCHEMBL7607008 | 0.81 | ITGB2 (0.42) | TSHRGLAPOLBGAAITGB2 | |
| SCHEMBL7610000 | 0.78 | PDE7A (0.49) | PDE7A | |
| SCHEMBL30574189 | 0.76 | TSHR (0.61) | TSHRGLAPOLBGAACYP3A4 | |
| SCHEMBL203216 | 0.76 | TSHR (0.61) | TSHRGLAPOLBGAACYP3A4 | |
| SCHEMBL709679 | 0.74 | GAA (0.59) | TSHRGLAPOLBGAAITGB2 | |
| Hydrochloric Acid SCHEMBL9827180 | 0.74 | TSHR (0.59) | TSHRGLAPOLBGAAITGB2 | |
| Fluoride SCHEMBL10883445 | 0.74 | TSHR (0.59) | TSHRGLAPOLBGAACYP3A4 | |
| Hydrochloric Acid SCHEMBL4383138 | 0.74 | TSHR (0.59) | TSHRGLAPOLBGAAITGB2 | |
| Methane SCHEMBL27686801 | 0.72 | TSHR (0.57) | TSHRGLAPOLBGAACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165504-A2 | INHIBITORS OF LFA-1 BINDING TO ICAMs AND USES THEREOF | ICOS CORPORATION (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059878-A2 | INHIBITORS OF LFA-1 BINDING TO ICAMs AND USES THEREOF | ICOS CORPORATION (US) | 2000-10-12 | — | — | WO | disclosed |