Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 2/20 | 0.42 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.42 |
| ▸ | ITGAL | P20701 | 2/20 | 0.42 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | KIT | P10721 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7610320 | 0.85 | ITGB2 (0.50) | ITGB2ICAM1ITGALPDE7ACYP3A4 | |
| SCHEMBL7606300 | 0.81 | TSHR (0.53) | ITGB2ICAM1ITGALPDE7ACYP3A4 | |
| SCHEMBL7605576 | 0.76 | PDE7A (0.48) | PDE7AMAPTALDH1A1 | |
| SCHEMBL7610172 | 0.72 | ITGB2 (0.50) | ITGB2ICAM1ITGALPDE7ACYP3A4 | |
| SCHEMBL7606214 | 0.72 | ITGB2 (0.50) | ITGB2ICAM1ITGALPDE7ACYP3A4 | |
| Hydrochloric Acid SCHEMBL7605651 | 0.71 | ITGB2 (0.53) | ITGB2ICAM1ITGALPDE7ACYP3A4 | |
| SCHEMBL18860366 | 0.70 | EPHB4 (0.39) | CYP3A4TSHRKITKDM4EMAPT | |
| SCHEMBL7610148 | 0.70 | ITGB2 (0.47) | ITGB2ICAM1ITGALPDE7ACYP3A4 | |
| SCHEMBL13385808 | 0.69 | TSHR (0.41) | CYP3A4TSHRKITKDM4EMEN1 | |
| SCHEMBL240923 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165504-A2 | INHIBITORS OF LFA-1 BINDING TO ICAMs AND USES THEREOF | ICOS CORPORATION (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059878-A2 | INHIBITORS OF LFA-1 BINDING TO ICAMs AND USES THEREOF | ICOS CORPORATION (US) | 2000-10-12 | — | — | WO | disclosed |