Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.35 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.34 |
| ▸ | PARP11 | Q9NR21 | 2/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.32 |
| ▸ | PRF1 | P14222 | 3/20 | 0.32 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.31 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.31 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.31 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.31 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.30 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL769021 | 0.75 | ACVRL1 (0.40) | PARP10PARP11CYP11B2CYP11B1BMPR1B | |
| SCHEMBL749146 | 0.67 | BMPR1A (0.40) | CYP11B2CYP11B1BMPR1BBMPR1AACVRL1 | |
| SCHEMBL750180 | 0.66 | CYP11B1 (0.41) | CYP11B2CYP11B1BMPR1BBMPR1AACVRL1 | |
| SCHEMBL743753 | 0.65 | ACVRL1 (0.40) | CYP11B2CYP11B1BMPR1BBMPR1AACVRL1 | |
| SCHEMBL3372095 | 0.62 | LRRK2 (0.50) | CYP11B2ACVR1MEN1KMT2ARAB9A | |
| SCHEMBL750197 | 0.62 | ACVRL1 (0.67) | CYP11B2CYP11B1BMPR1BBMPR1AACVRL1 | |
| SCHEMBL30635193 | 0.62 | BRD4 (0.49) | CYP2A6CYP11B2CYP11B1PTK2MEN1 | |
| SCHEMBL29135878 | 0.62 | BRD4 (0.49) | CYP2A6CYP11B2CYP11B1PTK2MEN1 | |
| SCHEMBL31260114 | 0.62 | CYP11B1 (0.70) | CYP11B2CYP11B1BMPR1BBMPR1AACVRL1 | |
| SCHEMBL22554142 | 0.61 | NPC1 (0.54) | CYP11B2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430011-A1 | 5-PYRIDIN-3-YL-1,3-DIHYDRO-INDOL-2-ON DERIVATIVES AND THEIR USE AS MODULATORS OF ALDOSTERONE SYNTHASE AND/OR CYP11B1 | Novartis AG (CH) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010130794-A1 | 5-PYRIDIN-3-YL-1,3-DIHYDRO-INDOL-2-ON DERIVATIVES AND THEIR USE AS MODULATORS OF ALDOSTERONE SYNTHASE AND/OR CYP11B1 | NOVARTIS AG (CH) | 2010-11-18 | — | — | WO | disclosed |