SCHEMBL7607569

SCHEMBL7607569

Fc1cccc(F)c1C#Cc1ccc(-c2ccccc2)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 2/20 0.50
CYP1A1 P04798 1/20 0.50
CYP1A2 P05177 1/20 0.50
CYP1B1 Q16678 1/20 0.50
APP P05067 1/20 0.42
GRM5 P41594 2/20 0.40
MAPT P10636 1/20 0.39
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
ATM Q13315 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
ALDH1A1 P00352 2/20 0.36
ACACB O00763 1/20 0.36
FFAR1 O14842 2/20 0.35
FFAR4 Q5NUL3 2/20 0.35
TAAR1 Q96RJ0 1/20 0.34
KIF11 P52732 1/20 0.34
NPC1 O15118 1/20 0.34
RAB9A P51151 1/20 0.34
MAPK1 P28482 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23956066 0.88 KCNH2 (0.44) KCNH2CYP1A1CYP1A2CYP1B1APP
SCHEMBL21387115 0.88 KCNH2 (0.47) KCNH2CYP1A1CYP1A2CYP1B1APP
SCHEMBL5134940 0.87 APP (0.57) KCNH2CYP1A2APPGRM5MAPT
SCHEMBL18674201 0.85 CYP1A1 (0.47) KCNH2CYP1A1CYP1A2CYP1B1APP
SCHEMBL24538167 0.82 KCNH2 (0.45) KCNH2CYP1A1CYP1A2CYP1B1APP
SCHEMBL19935634 0.81 KCNH2 (0.47) KCNH2CYP1A1CYP1A2CYP1B1APP
SCHEMBL15014376 0.79 CYP1A2 (0.46) KCNH2CYP1A1CYP1A2CYP1B1GRM5
SCHEMBL19682717 0.78 ALDH1A1 (0.35) KCNH2CYP1A1CYP1A2CYP1B1MAPT
SCHEMBL5886608 0.78 APP (0.71) KCNH2CYP1A1CYP1A2CYP1B1APP
SCHEMBL17104750 0.78 APP (0.58) CYP1A2APPMAPTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3670503-B1 COMPOUND, LIQUID CRYSTAL MEDIUM CONTAINING SAME, AND USE THEREOF SHIJIAZHUANG CHENGZHI YONGHUA DISPLAY MATERIALS CO LTD (CN) 2023-10-18 EP disclosed
EP-3433236-B1 CYANOPYRIMIDINE DERIVATIVES SUITABLE AS COMPONENTS IN LIQUID CRYSTAL MEDIA MERCK PATENT GMBH (DE) 2021-10-27 EP disclosed
WO-2021116080-A1 AROMATIC ISOTHIOCYANATES MERCK PATENT GMBH (DE) 2021-06-17 WO disclosed
EP-3670503-A1 COMPOUND, LIQUID CRYSTAL MEDIUM CONTAINING SAME, AND USE THEREOF Shijiazhuang Chengzhi Yonghua Display Material Co., Ltd. (CN) 2020-06-24 EP disclosed
EP-3504293-B1 LIQUID-CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2020-05-13 EP disclosed
WO-2017162707-A1 CYANOPYRIMIDINE DERIVATIVES SUITABLE AS COMPONENTS IN LIQUID CRYSTAL MEDIA MERCK PATENT GMBH (DE) 2017-09-28 WO disclosed
EP-1191082-A1 Liquid cristalline mixtures MERCK PATENT GmbH (DE) 2002-03-27 EP disclosed