Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 9/20 | 0.61 |
| ▸ | ADORA2B | P29275 | 8/20 | 0.61 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.57 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | NT5E | P21589 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3624008 | 1.00 | ADORA2A (0.61) | ADORA2AADORA2BADORA3ADORA1CYP2C19 | |
| SCHEMBL3624213 | 0.92 | ADORA2A (0.61) | ADORA2AADORA2BADORA3ADORA1CYP2C19 | |
| SCHEMBL5963020 | 0.91 | ADORA2A (0.67) | ADORA2AADORA2BADORA3ADORA1 | |
| SCHEMBL14420446 | 0.90 | ADORA2A (0.56) | ADORA2AADORA2BADORA3ADORA1CYP2C19 | |
| SCHEMBL5505948 | 0.90 | ADORA2A (0.56) | ADORA2AADORA2BADORA3ADORA1CYP2C19 | |
| SCHEMBL7611831 | 0.90 | LMNA (0.71) | ADORA2AADORA2BADORA3ADORA1LMNA | |
| SCHEMBL7611839 | 0.90 | LMNA (0.71) | ADORA2AADORA2BADORA3ADORA1LMNA | |
| SCHEMBL1527213 | 0.90 | ADORA2A (0.66) | ADORA2AADORA2BADORA3ADORA1CYP2C19 | |
| SCHEMBL12150807 | 0.90 | ADORA2A (0.66) | ADORA2AADORA2BADORA3ADORA1CYP2C19 | |
| SCHEMBL12031300 | 0.90 | ADORA2A (0.66) | ADORA2AADORA2BADORA3ADORA1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1198592-A4 | OLIGONUCLEOTIDES INCORPORATING BOTH 2-AMINOADENINE AND 5-SUBSTITUTED PYRIMIDINES | ISIS PHARMACEUTICALS INC (US) | 2002-09-18 | — | — | EP | disclosed |
| EP-1198592-A1 | OLIGONUCLEOTIDES INCORPORATING BOTH 2-AMINOADENINE AND 5-SUBSTITUTED PYRIMIDINES | ISIS PHARMACEUTICALS, INC. (US) | 2002-04-24 | — | — | EP | disclosed |
| US-6175004-B1 | REACTING AN OLIGONUCLEOTIDE COMPRISING A HALOGENATED PURINE NUCLEOSIDE WITH AMINE; FOR STRONGER HYBRIDIZATION; DIAGNOSIS; GENETIC ENGINEERING; ANTISENSE AGENTS | ISIS PHARMACEUTICALS, INC. | 2001-01-16 | — | — | US | disclosed |
| WO-2001002608-A1 | OLIGONUCLEOTIDES INCORPORATING BOTH 2-AMINOADENINE AND 5-SUBSTITUTED PYRIMIDINES | ISIS PHARMACEUTICALS, INC. (US) | 2001-01-11 | — | — | WO | disclosed |