Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.71 |
| ▸ | NT5E | P21589 | 1/20 | 0.71 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.71 |
| ▸ | ADORA2A | P29274 | 9/20 | 0.59 |
| ▸ | ADORA2B | P29275 | 8/20 | 0.59 |
| ▸ | CA5A | P35218 | 1/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.56 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7611839 | 1.00 | LMNA (0.71) | LMNANT5EHIF1AADORA2AADORA2B | |
| SCHEMBL5506193 | 0.91 | LMNA (0.68) | LMNANT5EHIF1AADORA2AADORA2B | |
| SCHEMBL3624008 | 0.90 | ADORA2A (0.61) | LMNANT5EHIF1AADORA2AADORA2B | |
| SCHEMBL7608233 | 0.90 | ADORA2A (0.61) | LMNANT5EHIF1AADORA2AADORA2B | |
| SCHEMBL7610042 | 0.90 | LMNA (0.77) | LMNANT5EHIF1AADORA2AADORA2B | |
| SCHEMBL7610049 | 0.90 | LMNA (0.77) | LMNANT5EHIF1AADORA2AADORA2B | |
| SCHEMBL1060588 | 0.85 | ADORA1 (0.72) | HIF1AADORA2AADORA2BADORA3ADORA1 | |
| SCHEMBL29408565 | 0.85 | ADORA1 (0.72) | HIF1AADORA2AADORA2BADORA3ADORA1 | |
| SCHEMBL28680450 | 0.85 | ADORA1 (0.72) | HIF1AADORA2AADORA2BADORA3ADORA1 | |
| SCHEMBL26370816 | 0.85 | ADORA1 (0.72) | HIF1AADORA2AADORA2BADORA3ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1198592-A4 | OLIGONUCLEOTIDES INCORPORATING BOTH 2-AMINOADENINE AND 5-SUBSTITUTED PYRIMIDINES | ISIS PHARMACEUTICALS INC (US) | 2002-09-18 | — | — | EP | disclosed |
| EP-1198592-A1 | OLIGONUCLEOTIDES INCORPORATING BOTH 2-AMINOADENINE AND 5-SUBSTITUTED PYRIMIDINES | ISIS PHARMACEUTICALS, INC. (US) | 2002-04-24 | — | — | EP | disclosed |
| US-6175004-B1 | REACTING AN OLIGONUCLEOTIDE COMPRISING A HALOGENATED PURINE NUCLEOSIDE WITH AMINE; FOR STRONGER HYBRIDIZATION; DIAGNOSIS; GENETIC ENGINEERING; ANTISENSE AGENTS | ISIS PHARMACEUTICALS, INC. | 2001-01-16 | — | — | US | disclosed |
| WO-2001002608-A1 | OLIGONUCLEOTIDES INCORPORATING BOTH 2-AMINOADENINE AND 5-SUBSTITUTED PYRIMIDINES | ISIS PHARMACEUTICALS, INC. (US) | 2001-01-11 | — | — | WO | disclosed |