Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.41 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.44 |
| ▸ | CXCR4 | P61073 | 8/20 | 0.43 |
| ▸ | EED | O75530 | 3/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7183846 | 0.96 | GBA1 (0.47) | GBA1CXCR4EEDHRH3MEN1 | |
| Bromide SCHEMBL9096258 | 0.87 | EED (0.41) | GBA1CXCR4EEDHRH3MEN1 | |
| SCHEMBL9015445 | 0.87 | GBA1 (0.41) | GBA1CXCR4EEDHRH3MEN1 | |
| SCHEMBL30589132 | 0.87 | GBA1 (0.61) | GBA1EEDKMT2A | |
| SCHEMBL9339492 | 0.81 | KCNJ1 (0.47) | HRH3KMT2ATDP1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL10374853 | 0.79 | GBA1 (0.43) | GBA1TDP1 | |
| SCHEMBL9828599 | 0.78 | GBA1 (0.64) | GBA1EED | |
| SCHEMBL20806640 | 0.77 | GBA1 (0.63) | GBA1CXCR4EEDHRH3MEN1 | |
| Hydrochloric Acid SCHEMBL8217711 | 0.75 | IDO1 (0.40) | GBA1EED | |
| SCHEMBL9211556 | 0.75 | KMT2A (0.45) | KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1223166-A1 | Linked cyclic polyamines with activity against hiv. | AnorMED Inc. (CA) | 2002-07-17 | — | — | EP | disclosed |