Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 2/20 | 0.64 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | CCR3 | P51677 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | EED | O75530 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30589132 | 0.92 | GBA1 (0.61) | GBA1SLC6A2SLC6A4SLC6A3POLB | |
| SCHEMBL1742163 | 0.91 | GBA1 (0.63) | GBA1SLC6A2SLC6A4SLC6A3CCR3 | |
| Hydrochloric Acid SCHEMBL21523631 | 0.89 | GBA1 (0.61) | GBA1SLC6A2SLC6A4SLC6A3CCR3 | |
| SCHEMBL4892499 | 0.88 | GBA1 (0.78) | GBA1SLC6A2SLC6A4SLC6A3CCR3 | |
| SCHEMBL4889591 | 0.88 | GBA1 (0.78) | GBA1SLC6A2SLC6A4SLC6A3CCR3 | |
| SCHEMBL892689 | 0.88 | GBA1 (0.78) | GBA1SLC6A2SLC6A4SLC6A3CCR3 | |
| SCHEMBL8547993 | 0.84 | EED (0.61) | GBA1SLC6A2SLC6A4SLC6A3POLB | |
| SCHEMBL1761058 | 0.84 | EED (0.61) | GBA1SLC6A2SLC6A4SLC6A3POLB | |
| SCHEMBL3473180 | 0.84 | EED (0.61) | GBA1SLC6A2SLC6A4SLC6A3POLB | |
| SCHEMBL27114036 | 0.83 | GBA1 (0.55) | GBA1CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0187371-B1 | SUBSTITUTED ISOQUINOLINESULFONYL COMPOUNDS | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1991-06-19 | — | — | EP | disclosed |
| US-4678783-A | CARDIOVASCULAR DISORDERS, HYPOTENSIVES, ARTERIOSCLEROSIS | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1987-07-07 | — | — | US | disclosed |
| EP-0187371-A2 | Substituted isoquinolinesulfonyl compounds | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1986-07-16 | — | — | EP | disclosed |