Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 2/20 | 0.65 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SETD2 | Q9BYW2 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7609472 | 0.94 | OPRK1 (0.69) | OPRK1RPS6KA2MAPK14LCKMAP2K1 | |
| SCHEMBL2971456 | 0.91 | OPRK1 (0.57) | OPRK1RPS6KA2MAPK14LCKMAP2K1 | |
| SCHEMBL6484951 | 0.88 | MAPK14 (0.60) | OPRK1MAPK14LCKMAP2K1NTRK1 | |
| SCHEMBL2970301 | 0.86 | OPRK1 (0.61) | OPRK1MAPK14LCKMAP2K1NTRK1 | |
| SCHEMBL6476258 | 0.83 | OPRK1 (0.62) | OPRK1MAPK14LCKMAP2K1NTRK1 | |
| SCHEMBL7807945 | 0.81 | OPRK1 (0.56) | OPRK1MAPK14LCKMAP2K1NTRK1 | |
| SCHEMBL7853300 | 0.81 | OPRK1 (0.56) | OPRK1MAPK14LCKMAP2K1SETD2 | |
| SCHEMBL6974083 | 0.79 | MAPK14 (0.59) | MAPK14 | |
| SCHEMBL6476055 | 0.77 | MAPK14 (0.67) | OPRK1MAPK14LCKMAP2K1 | |
| SCHEMBL6490264 | 0.76 | MAPK14 (0.58) | OPRK1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102743-B1 | AMIDE DERIVATIVES WHICH ARE USEFUL AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2002-07-24 | — | — | EP | disclosed |